Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive
understanding of distinct subpopulations and their functional relevance in human satellite …

Satellite cells are the chief contributor to skeletal muscle growth and regeneration. The study
of mouse satellite cells has accelerated in recent years due to technical advancements in …

Satellite cells play a central role in mediating the growth and regeneration of skeletal
muscle. However, whether satellite cells are stem cells, committed progenitors, or …

Satellite cells are adult skeletal muscle stem cells that are quiescent and constitute a poorly
defined heterogeneous population. Using transgenic Tg: Pax7-nGFP mice, we show that …

Identification of human satellite cells that fulfill muscle stem cell criteria is an unmet need in
regenerative medicine. This hurdle limits understanding how closely muscle stem cell …

Background Fluorescent-activated cell sorting (FACS) has enabled the direct isolation of
highly enriched skeletal muscle stem cell, or satellite cell, populations from postnatal tissue …

Distinct cell populations with regenerative capacity have been reported to contribute to
myofibres after skeletal muscle injury, including non-satellite cells as well as myogenic …

Quiescent satellite cells are responsible for the repair of post-natal skeletal muscle. These
cells are easily identified by their unique morphology within skeletal muscle as well as by …

Stem cell heterogeneity is recognized as functionally relevant for tissue homeostasis and
repair. The identity, context dependence, and regulation of skeletal muscle satellite cell (SC) …

Muscle satellite cells promote regeneration and could potentially improve gene delivery for
treating muscular dystrophies. Human satellite cells are scarce; therefore, clinical …