Identifying the challenges for successful pharmacotherapeutic management of sarcopenia

GS Lynch - Expert opinion on pharmacotherapy, 2022 - Taylor & Francis
Skeletal muscle is essential for life and maintaining muscle health is especially important for
the quality of life that contributes to healthy longevity. Muscle contraction is responsible for …

The Current Landscape of Pharmacotherapies for Sarcopenia

G Bahat, S Ozkok - Drugs & Aging, 2024 - Springer
Sarcopenia is a skeletal muscle disorder characterized by progressive and generalized
decline in muscle mass and function. Although it is mostly known as an age-related disorder …

Current pharmacotherapies for sarcopenia

JP Hardee, GS Lynch - Expert Opinion on Pharmacotherapy, 2019 - Taylor & Francis
Introduction: Sarcopenia, the age-related loss of skeletal muscle mass and function, is a
global health problem that contributes to the development of physical disability, morbidity …

Development of Pharmacotherapies for the Treatment of Sarcopenia

D Rooks, R Roubenoff - The Journal of frailty & aging, 2019 - Springer
Sarcopenia, the associated loss of skeletal muscle mass and strength and impaired physical
function seen with aging, is a growing, global public health challenge in need of accepted …

Sarcopenia: no consensus, no diagnostic criteria, and no approved indication—How did we get here?

WJ Evans, J Guralnik, P Cawthon, J Appleby, F Landi… - Geroscience, 2024 - Springer
In addition to the role of skeletal muscle in movement and locomotion, muscle plays a critical
role in a broad array of metabolic processes that can contribute to improved health or risk of …

Emerging drugs for sarcopenia: age-related muscle wasting

GS Lynch - Expert opinion on emerging drugs, 2004 - Taylor & Francis
Sarcopenia is the term widely used to describe the progressive loss of muscle mass with
advancing age. Even before significant muscle wasting becomes apparent, ageing is …

Novel therapies for sarcopenia: ameliorating age-related changes in skeletal muscle

GS Lynch - Expert Opinion on Therapeutic Patents, 2002 - Taylor & Francis
Among the most serious consequences of ageing are its effects on skeletal muscle structure
and function. Ageing is associated with a progressive loss of muscle mass (sarcopenia) …

Update on emerging drugs for sarcopenia–age-related muscle wasting

GS Lynch - Expert Opinion on Emerging Drugs, 2008 - Taylor & Francis
Sarcopenia–the progressive loss of muscle mass with advancing age is characterised by a
deterioration of muscle quantity and quality leading to a gradual slowing of movement and a …

Considerations in the development of drugs to treat sarcopenia

EP Brass, KE Sietsema - Journal of the American Geriatrics …, 2011 - Wiley Online Library
Sarcopenia describes reduced skeletal muscle mass and impaired muscle function
associated with aging and with a variety of chronic diseases prevalent in the aging …

Sarcopenia: relocating the forest among the trees

TW Buford - Toxicologic Pathology, 2017 - journals.sagepub.com
As life expectancy continues to rise worldwide, health concerns associated with advanced
age are increasingly becoming prominent public health concerns. Among these concerns …