Atherosclerosis and inflammation: Mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1/LFA-1 pathway in atherogenesis

T Watanabe, J Fan - International Journal of Cardiology, 1998 - Elsevier
Recent investigations have reanimated the view that there exists a possible link between
atherosclerosis and inflammation. Adhesion of monocytes as well as T lymphocytes to the …

Inhibition of mononuclear cell recruitment in aortic intima by treatment with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies in hypercholesterolemic rats …

Q Nie, J Fan, S Haraoka, T Shimokama… - … investigation; a journal …, 1997 - europepmc.org
To investigate the mechanism (s) for mononuclear cell recruitment in the arterial wall during
the development of atherosclerosis, we studied intercellular adhesion molecule-1 (ICAM-1) …

Expression of intercellular adhesion molecule-1 on rat vascular smooth muscle cells by pro-inflammatory cytokines

U Ikeda, M Ikeda, Y Seino, M Takahashi, T Kasahara… - Atherosclerosis, 1993 - Elsevier
Infiltration of mononuclear cells is an early pathological finding in human and experimental
atherosclerosis. However, the cellular and molecular basis for cell infiltration is incompletely …

Role of cell adhesion molecules and immune-cell migration in the initiation, onset and development of atherosclerosis

Z Chi, AJ Melendez - Cell adhesion & migration, 2007 - Taylor & Francis
Atherosclerosis is currently the leading factor of death in developed countries. It is now
recognized as a chronic immune-inflammatory disease, whose initial stages involve the …

Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model

L Fotis, G Agrogiannis, IS Vlachos, A Pantopoulou… - In vivo, 2012 - iv.iiarjournals.org
Backround: Members of the immunoglobulin superfamily of endothelial adhesion molecules,
vascular cell adhesion molecule (VCAM-1) and intercellular cell adhesion molecule (ICAM …

Adhesion molecules and atherogenesis

Y Huo, K Ley - Acta Physiologica Scandinavica, 2001 - Wiley Online Library
Atherosclerosis is an inflammatory disease of the vessel wall characterized by monocyte
infiltration in response to pro‐atherogenic factors such as oxidized lipids. Recently, the role …

Alterations in circulating intercellular adhesion molecule-1 and L-selectin: further evidence for chronic inflammation in ischemic heart disease

WH Haught, M Mansour, R Rothlein, TK Kishimoto… - American heart …, 1996 - Elsevier
Atherosclerosis is increasingly thought to be a chronic inflammatory disease. Inflammation
requires transmigration of leukocytes from the circulation to the tissues. Adhesion of …

Cellular adhesion molecules and cardiovascular disease. Part I. Their expression and role in atherogenesis

SA Hope, IT Meredith - Internal medicine journal, 2003 - Wiley Online Library
Atherosclerosis is now recognized to be an inflammatory disease, and several inflammatory
markers have been shown to be associated with both the presence and future risk of …

Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed …

K Iiyama, L Hajra, M Iiyama, H Li, M DiChiara… - Circulation …, 1999 - Am Heart Assoc
The recruitment of mononuclear leukocytes and formation of intimal macrophage-rich
lesions at specific sites of the arterial tree are key events in atherogenesis. Inducible …

Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse

Y Nakashima, EW Raines, AS Plump… - … , and vascular biology, 1998 - Am Heart Assoc
Focal recruitment of monocytes and lymphocytes is one of the earliest detectable cellular
responses in the formation of lesions of atherosclerosis. This localized accumulation of …