The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and
ulcerative colitis (UC), involves the interaction between environmental factors in the …

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents
from the interstitium. The single layer of intestinal epithelial cells (IECs) serves as a dynamic …

The etiology of human inflammatory bowel diseases (IBDs) is believed to involve
inappropriate host responses to the complex commensal microbial flora in the gut, although …

Intestinal mucosal barrier function is the capacity of the intestine to provide adequate
containment of luminal microorganisms and molecules while preserving the ability to absorb …

The intestinal barrier is composed of several essential elements including luminal enzymes,
bile acids, water layer, epithelial layer, and enterocyte layer. It acts as a dynamic interface …

The gut mucosa is constantly challenged by a bombardment of foreign antigens and
environmental microorganisms. As such, the precise regulation of the intestinal barrier …

Intestinal barrier dysfunction is a main feature of the inflammatory bowel diseases (IBD),
Crohn's disease and ulcerative colitis. Leak flux diarrhoea and a facilitated uptake of …

The intestinal epithelium can be easily disrupted during gut inflammation as seen in
inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease. For a long …

Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results
from host-microbial interactions in a genetically susceptible individual. IBDs are a group of …

The human gut relies on several cellular and molecular mechanisms to allow for an intact
and dynamical intestinal barrier. Normally, only small amounts of luminal content pass the …