[HTML][HTML] Reduction of breast cancer extravasation via vibration activated osteocyte regulation

X Song, CY Lin, X Mei, L Wang, L You - Iscience, 2022 - cell.com
Physical exercise benefits breast cancer patients by reducing cancer progression and
promoting bone health. However, intense exercise is physically challenging for bedridden …

[HTML][HTML] Yoda1 enhanced low-magnitude high-frequency vibration on osteocytes in regulation of MDA-MB-231 breast cancer cell migration

CY Lin, X Song, Y Ke, A Raha, Y Wu, M Wasi, L Wang… - Cancers, 2022 - mdpi.com
Simple Summary Bone metastasis is a severe complication that contributes significantly to
the morbidity and mortality of breast cancer patients. Although mechanical loading was …

Microfluidic platform for studying osteocyte mechanoregulation of breast cancer bone metastasis

X Mei, K Middleton, D Shim, Q Wan, L Xu… - Integrative …, 2019 - academic.oup.com
Bone metastasis is a common, yet serious, complication of breast cancer. Breast cancer
cells that extravasate from blood vessels to the bone devastate bone quality by interacting …

[HTML][HTML] Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity

X Yi, LE Wright, GM Pagnotti, G Uzer, KM Powell… - Bone Research, 2020 - nature.com
Exercise benefits the musculoskeletal system and reduces the effects of cancer. The effects
of exercise are multifactorial, where metabolic changes and tissue adaptation influence …

Effects of whole-body vibration on breast cancer bone metastasis and vascularization in mice

T Matsumoto, A Mukohara - Calcified Tissue International, 2022 - Springer
We evaluated whether whole-body vibration (WBV) prevented bone loss induced by breast
cancer (BC) metastasis and the involvement of bone marrow vasculature. One day after …

[HTML][HTML] Estrogen receptor α signaling in osteoblasts is required for mechanotransduction in bone fracture healing

L Steppe, BT Krüger, MEA Tschaffon… - … in Bioengineering and …, 2021 - frontiersin.org
Biomechanical stimulation by whole-body low-magnitude high-frequency vibration (LMHFV)
has demonstrated to provoke anabolic effects on bone metabolism in both non-osteoporotic …

[HTML][HTML] Enhancing anti-tumor potential: low-intensity vibration suppresses osteosarcoma progression and augments MSCs' tumor-suppressive abilities

X Xiong, Q Huo, K Li, C Cui, C Chang, C Park… - Theranostics, 2024 - ncbi.nlm.nih.gov
Abstract Rationale: Osteosarcoma (OS), a common malignant bone tumor, calls for the
investigation of novel treatment strategies. Low-intensity vibration (LIV) presents itself as a …

[HTML][HTML] Low‑level mechanical vibration enhances osteoblastogenesis via a canonical Wnt signaling‑associated mechanism

H Gao, M Zhai, P Wang, X Zhang… - Molecular …, 2017 - spandidos-publications.com
Osteoporosis is a skeletal metabolic disease characterized by reduced bone mass and a
high susceptibility to fractures, in which osteoblasts and osteoclasts are highly involved in …

Effects of mechanical vibration on cell morphology, proliferation, apoptosis, and cytokine expression/secretion in osteocyte‐like MLO‐Y4 cells exposed to high glucose

T Sun, Z Yan, J Cai, X Shao, D Wang… - Cell Biology …, 2020 - Wiley Online Library
Diabetic patients exhibit significant bone deterioration. Our recent findings demonstrate that
mechanical vibration is capable of resisting diabetic bone loss, whereas the relevant …

[HTML][HTML] Influence of low-magnitude high-frequency vibration on bone cells and bone regeneration

L Steppe, A Liedert, A Ignatius… - … in bioengineering and …, 2020 - frontiersin.org
Bone is a mechanosensitive tissue for which mechanical stimuli are crucial in maintaining its
structure and function. Bone cells react to their biomechanical environment by activating …