Pathophysiology of aortic stenosis and future perspectives for medical therapy

KH Zheng, E Tzolos, MR Dweck - Cardiology clinics, 2020 - cardiology.theclinics.com
Calcific aortic stenosis (AS) is the most common valve disease in the high-income countries
and is set to become a major health care burden with an aging population. 1 It is …

Great debate: all patients with asymptomatic severe aortic stenosis need valve replacement

B Iung, L Pierard, J Magne… - European Heart …, 2023 - academic.oup.com
Department of Cardiology III—Adult Congenital and Valvular Heart Disease, University
Hospital Muenster, Muenster, Germany Aortic stenosis (AS) has become a significant health …

Calcific aortic stenosis: from bench to the bedside—emerging clinical and cellular concepts

NM Rajamannan, B Gersh, RO Bonow - Heart, 2003 - heart.bmj.com
Calcific aortic stenosis is the third most common cause of aortic valve disease in developed
countries. This condition increases in prevalence with advancing age, afflicting 2–3% of the …

Nonrheumatic calcific aortic stenosis: an overview from basic science to pharmacological prevention

A Parolari, C Loardi, L Mussoni… - European journal of …, 2009 - academic.oup.com
Calcific aortic stenosis is a frequent degenerative disease, which represents the most
common indication for adult heart valve surgery, and carries substantial morbidity and …

Calcific aortic stenosis

BR Lindman, MA Clavel, P Mathieu, B Iung… - Nature reviews Disease …, 2016 - nature.com
Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed
countries. It is characterized by progressive fibro-calcific remodelling and thickening of the …

Prevention of calcific aortic valve stenosis—fact or fiction?

PJ Cawley, CM Otto - Annals of medicine, 2009 - Taylor & Francis
Valve replacement is the only long-term effective treatment for calcific aortic valve stenosis.
However, this treatment is aimed only at patients with advanced leaflet disease and …

Calcific aortic stenosis: a disease ready for prime time

NM Rajamannan - Circulation, 2006 - Am Heart Assoc
Calcific aortic stenosis is the number 1 cause for surgical valve replacement in the United
States and Europe. In 2006, surgical valve replacement still remains the number 1 indication …

Emerging medical treatments for aortic stenosis: statins, angiotensin converting enzyme inhibitors, or both?

DE Newby, SJ Cowell, NA Boon - Heart, 2006 - heart.bmj.com
Aortic stenosis is the most common adult heart valve condition seen in the Western world
and its incidence continues to rise. No established disease modifying treatments retard …

Calcific aortic stenosis—time to look more closely at the valve

CM Otto - New England Journal of Medicine, 2008 - Mass Medical Soc
Calcific aortic stenosis is a progressive disease that results in stiff valve leaflets with
eventual obstruction to left ventricular outflow. Once symptoms occur, valve replacement is …

Calcific aortic stenosis: same old story?

SJ Cowell, DE Newby, NA Boon, AT Elder - Age and ageing, 2004 - academic.oup.com
Calcific aortic stenosis is the commonest adult valvular heart condition seen in the western
world. Its prevalence is continuing to rise, with predominance in older patients who are …