[HTML][HTML] IUPHAR review–Data-driven computational drug repurposing approaches for opioid use disorder

Z Gao, P Ding, R Xu - Pharmacological Research, 2024 - Elsevier
Abstract Opioid Use Disorder (OUD) is a chronic and relapsing condition characterized by
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …

Machine-learning repurposing of DrugBank compounds for opioid use disorder

H Feng, J Jiang, GW Wei - Computers in biology and medicine, 2023 - Elsevier
Opioid use disorder (OUD) is a chronic and relapsing condition that involves the continued
and compulsive use of opioids despite harmful consequences. The development of …

Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses

M Zhou, QQ Wang, C Zheng, A John Rush… - Molecular …, 2021 - nature.com
Morbidity and mortality from opioid use disorders (OUD) and other substance use disorders
(SUD) is a major public health crisis, yet there are few medications to treat them. There is an …

[HTML][HTML] Computational Approaches in Drug Repurposing

CC Ekeomodi, KI Obetta, ML Okolocha… - … and Opportunities in …, 2023 - intechopen.com
Drug repurposing is a term applied to finding a new therapeutic and pharmacological
indication for an existing drug molecule with a known indication. Repurposing existing drugs …

An analytical review of computational drug repurposing

SS Sadeghi, MR Keyvanpour - IEEE/ACM transactions on …, 2019 - ieeexplore.ieee.org
Drug repurposing is a vital function in pharmaceutical fields and has gained popularity in
recent years in both the pharmaceutical industry and research community. It refers to the …

Computational drug repurposing: classification of the research opportunities and challenges

SS Sadeghi, MR Keyvanpour - Current Computer-Aided Drug …, 2020 - ingentaconnect.com
Background: Drug repurposing has grown significantly in recent years. Research and
innovation in drug repurposing are extremely popular due to its practical and explicit …

[HTML][HTML] Evaluating the performance of drug-repurposing technologies

J Schuler, Z Falls, W Mangione, ML Hudson… - Drug discovery today, 2022 - Elsevier
Drug-repurposing technologies are growing in number and maturing. However,
comparisons to each other and to reality are hindered because of a lack of consensus with …

[图书][B] Computational methods for drug repurposing

Q Vanhaelen - 2019 - Springer
It is known that despite large R&D resources and expenses, the conventional drug discovery
process has become increasingly time-consuming and elicits a relatively high attrition rate …

Implementation of a pipeline using disease-disease associations for computational drug repurposing

P Balasundaram, R Kanagavelu, N James… - … Methods for Drug …, 2019 - Springer
Drug repurposing is a powerful technique which has been recently employed in both
industry and academia to discover and validate previously approved drugs for new …

[PDF][PDF] Computational drug repurposing: research opportunities and challenges classification

SS Sadeghi, MR Keyvanpour - Curr. Comput. Aided Drug Des, 2019 - researchgate.net
Background: Drug repurposing has grown significantly in recent years. Research and
innovation in drug repurposing are extremely popular due to its practical and explicit …