Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction

JS Barry, PJ Rozance, LD Brown… - Experimental …, 2016 - journals.sagepub.com
Unlike other visceral organs, myocardial weight is maintained in relation to fetal body weight
in intrauterine growth restriction (IUGR) fetal sheep despite hypoinsulinemia and global …

Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction

JS Barry, ML Davidsen, SW Limesand… - Experimental …, 2006 - journals.sagepub.com
Developmental changes in ovine myocardial glucose transporters and insulin signaling
following hyperthermia-induced intrauterine fetal growth restriction (IUGR) were the focus of …

Maternal nutrient restriction during early to mid gestation up-regulates cardiac insulin-like growth factor (IGF) receptors associated with enlarged ventricular size in …

F Dong, SP Ford, CX Fang, MJ Nijland… - Growth hormone & IGF …, 2005 - Elsevier
Intrauterine undernutrition is associated with a high incidence of cardiovascular diseases in
adulthood. We previously showed that maternal nutrient restriction during early to mid …

Reduced in utero substrate supply decreases mitochondrial abundance and alters the expression of metabolic signalling molecules in the fetal sheep heart

CG Dimasi, JRT Darby, SKS Cho… - The Journal of …, 2023 - Wiley Online Library
Babies born with fetal growth restriction (FGR) are at higher risk of developing
cardiometabolic diseases across the life course. The reduction in substrate supply to the …

Maternal undernutrition in late gestation increases IGF2 signalling molecules and collagen deposition in the right ventricle of the fetal sheep heart

JRT Darby, IC McMillen… - The Journal of physiology, 2018 - Wiley Online Library
Key points This study investigates the impact of decreased fetal plasma glucose
concentrations on the developing heart in late gestation, by subjecting pregnant ewes to a …

Alteration of cardiac glucose metabolism in association to low birth weight: experimental evidence in lambs with left ventricular hypertrophy

KCW Wang, CH Lim, IC McMillen, JA Duffield… - Metabolism, 2013 - Elsevier
Objective Intrauterine growth restriction that results in low birth weight (LBW) has been
linked to the onset of pathological cardiac hypertrophy. An altered transition from a fetal to …

Mitochondrial respiration is lower in the intrauterine growth‐restricted fetal sheep heart

EI Chang, J Stremming, LA Knaub… - The Journal of …, 2024 - Wiley Online Library
Fetuses affected by intrauterine growth restriction have an increased risk of developing heart
disease and failure in adulthood. Compared with controls, late gestation intrauterine growth …

Enhanced insulin secretion and insulin sensitivity in young lambs with placental insufficiency-induced intrauterine growth restriction

LE Camacho, X Chen, WW Hay Jr… - American Journal of …, 2017 - journals.physiology.org
Intrauterine growth restriction (IUGR) is associated with persistent metabolic complications,
but information is limited for IUGR infants. We determined glucose-stimulated insulin …

Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction

SW Limesand, PJ Rozance, D Smith… - American Journal of …, 2007 - journals.physiology.org
In this study we determined body weight-specific fetal (umbilical) glucose uptake (UGU),
utilization (GUR), and production rates (GPR) and insulin action in intrauterine growth …

The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri‐implantation undernutrition in sheep

DM Burrage, L Braddick, JK Cleal… - The Journal of …, 2009 - Wiley Online Library
Undernourished late gestation fetuses display asymmetric growth restriction, suggestive of a
redistribution of nutritional resources. The modification of fetal organ blood supply in …