[HTML][HTML] Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications

AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …

SARS-CoV-2 inhibits NRF2-mediated antioxidant responses in airway epithelial cells and in the lung of a murine model of infection

Y Qu, A Haas de Mello, DR Morris… - Microbiology …, 2023 - Am Soc Microbiol
Several viruses have been shown to modulate the transcription factor nuclear factor
erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe …

[HTML][HTML] SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway

RS Hamad, HM Al-Kuraishy, A Alexiou… - Cell Stress and …, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel
severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and …

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

R Cecchini, AL Cecchini - Medical hypotheses, 2020 - Elsevier
Since the WHO declared COVID-19 a pandemic, a great effort has been made to understand
this serious disease. Thousands of studies are being devoted to understanding its …

Oxidative stress‐related mechanisms in SARS‐CoV‐2 infections

J Wieczfinska, P Kleniewska… - Oxidative medicine and …, 2022 - Wiley Online Library
The COVID‐19 pandemic caused relatively high mortality in patients, especially in those
with concomitant diseases (ie, diabetes, hypertension, and chronic obstructive pulmonary …

SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …

[HTML][HTML] Metabolic implications of oxidative stress and inflammatory process in SARS-CoV-2 pathogenesis: therapeutic potential of natural antioxidants

GE Forcados, A Muhammad, OO Oladipo… - Frontiers in Cellular …, 2021 - frontiersin.org
COVID-19 is a zoonotic disease with devastating economic and public health impacts
globally. Being a novel disease, current research is focused on a clearer understanding of …

[HTML][HTML] Involvement of oxidative stress and the innate immune system in SARS-CoV-2 infection

EM Kozlov, E Ivanova, AV Grechko, WK Wu… - Diseases, 2021 - mdpi.com
The emergence of the novel coronavirus in December 2019 in China marked the beginning
of a pandemic that impacted healthcare systems and economic life all over the world. The …

[HTML][HTML] Antioxidants and COVID-19

S DE FLORA, R Balansky… - Journal of preventive …, 2021 - ncbi.nlm.nih.gov
Oxidative mechanisms are not only involved in chronic degenerative diseases but also in
infectious diseases, among which viral respiratory diseases. Antioxidants have the capability …

[HTML][HTML] Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19

JM McCord, BM Hybertson, A Cota-Gomez, KP Geraci… - Antioxidants, 2020 - mdpi.com
Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …