Mutations at five positions in the Plasmodium falciparum multidrug-resistance gene 1
(pfmdr1), initially thought to confer resistance to chloroquine, have been associated with in …

It has been postulated that chloroquine resistance may be associated with a single point
mutation at codon 86 of the Plasmodium falciparum multidrug resistance 1 (pfmdr 1) gene …

To assess the level of resistance to chloroquine (CQ) of Plasmodium falciparum in The
Gambia in 1995–1996 we measured susceptibility in vivo by quantifying parasitaemia of …

The feasibility of using mutations at codons 86 and 1246 of the pfmdr1 as predictors of
chloroquine resistance was investigated in southern African isolates of Plasmodium …

Resistance of Plasmodium falciparum to many therapeutic agents is an increasing problem
in most endemic areas. The role of the mdr-like gene products of P. falciparum in resistance …

The efficacy of chloroquine in the treatment of uncomplicated falciparum malaria in Africa is
heavily compromised by high levels of drug resistance. The occurrence of active site …

During an epidemic of Plasmodium falciparum malaria in Chogoria, Kenya, P. falciparum
DNA was collected from 24 cases of severe malaria admitted to hospital for parenteral …

Resistance to quinoline-containing compound has been associated with the Plasmodium
falciparum multidrug resistance 1 (pfmdr1) gene. We analyzed wild P. falciparum isolates …

Of 16 Plasmodium falciparum samples from Guinea-Bissau showing chloroquine resistance,
11 had the A754T mutation for Tyr86. 5 sensitive samples did not have this mutation. This …

The emergence of drug-resistance poses a major obstacle to the control of malaria. A
homolog of the major multidrug-transporter in mammalian cells was identified, Plasmodium …