Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Understanding the genetic underpinning of early human development is of great interest not
only for basic developmental and stem cell biology but also for regenerative medicine …

Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to
study the regulatory mechanisms that facilitate cellular transitions in a human context. To …

In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …

Establishing the different lineages of the early mammalian embryo takes place over several
days and several rounds of cell divisions from the fertilized egg. The resulting blastocyst …

Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

Cells of the early mammalian embryo, including pluripotent embryonic stem (ES) cells and
primordial germ cells (PGCs), are epigenetically dynamic and heterogeneous. During early …

Embryonic stem cells (ESCs) are characterized by their broad developmental potential and
the capacity to self-renew. The advent of high-throughput technologies has facilitated …

Fertilization is a very complex biological process that requires the perfect cooperation
between two highly specialized cells: the male and female gametes. The oocyte provides …

Highlights•Single-cell atlases of mouse embryogenesis reveal epigenetic regulator
dynamics in early development.•Genetic perturbation in combination with single-cell …