Shikonin derivatives for cancer prevention and therapy

JC Boulos, M Rahama, MEF Hegazy, T Efferth - Cancer letters, 2019 - Elsevier
Phytochemicals gained considerable interest during the past years as source to develop
new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a …

Synthesis, biological function and evaluation of Shikonin in cancer therapy

F Wang, X Yao, Y Zhang, J Tang - Fitoterapia, 2019 - Elsevier
Shikonin is a natural compound isolated from herbs and traditional medicines that have
been used in a number of countries to treat various illnesses including inflammation, virus …

Pharmacological properties and derivatives of shikonin—A review in recent years

C Guo, J He, X Song, L Tan, M Wang, P Jiang… - Pharmacological …, 2019 - Elsevier
Shikonin is the major bioactive component extracted from the roots of Lithospermum
erythrorhizon which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent …

Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy

I Andujar, MC Recio, RM Giner… - Current medicinal …, 2013 - ingentaconnect.com
Shikonin is the major constituent of the root of Lithospermum erythrorhizon, which has been
used in traditional Chinese medicine to treat external wounds, burns, or dermatitis for …

Shikonin and its derivatives: a patent review

R Wang, R Yin, W Zhou, D Xu, S Li - Expert opinion on therapeutic …, 2012 - Taylor & Francis
Introduction: Shikonin and its derivatives are the main components of red pigment extracts
from Lithospermum erythrorhizon, whose medicinal properties have been confirmed for a …

Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells

F Singh, D Gao, MG Lebwohl, H Wei - Cancer letters, 2003 - Elsevier
Shikonin isolated from the roots of the Chinese herb Lithospermum erythrorhizon has been
associated with anti-inflammatory properties. We evaluated shikonin's chemotherapeutic …

Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms …

M Valipour - European journal of medicinal chemistry, 2022 - Elsevier
Shikonin and its enantiomeric analogue, alkaninn, are prevailing natural lead compounds in
the drug discovery and development of anticancer agents. Despite having numerous …

[HTML][HTML] Pharmacological properties of shikonin–a review of literature since 2002

I Andújar, JL Ríos, RM Giner, MC Recio - Planta medica, 2013 - thieme-connect.com
The naphthoquinone shikonin is the main active principle of Zicao, a traditional Chinese
herbal medicine made from the dried root of Lithospermum erythrorhizon. Studies carried …

Cellular pharmacology studies of shikonin derivatives

X Chen, L Yang, JJ Oppenheim… - Phytotherapy …, 2002 - Wiley Online Library
The naphthoquinone pigment, shikonin, isolated from Lithospermum erythrorhizon Sieb. et
Zucc.(Boraginaceae) and its derivatives are the active components isolated from the …

Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

Q Sun, T Gong, M Liu, S Ren, H Yang, S Zeng, H Zhao… - Phytomedicine, 2022 - Elsevier
Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …