An antiviral role for TRIM14 in Ebola virus infection

M Kuroda, PJ Halfmann, LB Thackray… - The Journal of …, 2023 - academic.oup.com
Ebola virus (EBOV) is a highly pathogenic virus that encodes 7 multifunctional structural
proteins. Multiple host factors have been reported to interact with the EBOV proteins. Here …

The host E3-ubiquitin ligase TRIM6 ubiquitinates the Ebola virus VP35 protein and promotes virus replication

P Bharaj, C Atkins, P Luthra, MI Giraldo… - Journal of …, 2017 - Am Soc Microbiol
Ebola virus (EBOV), a member of the Filoviridae family, is a highly pathogenic virus that
causes severe hemorrhagic fever in humans and is responsible for epidemics throughout …

Ebolavirus VP35 is a multifunctional virulence factor

DW Leung, KC Prins, CF Basler, GK Amarasinghe - Virulence, 2010 - Taylor & Francis
Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic
fever during sporadic outbreaks, and no approved treatments are currently available. The …

VP24 is a molecular determinant of Ebola virus virulence in guinea pigs

M Mateo, C Carbonnelle, O Reynard… - The Journal of …, 2011 - academic.oup.com
In sharp contrast to human and nonhuman primates, guinea pigs and some other mammals
resist Ebola virus (EBOV) replication and do not develop illness upon virus inoculation …

Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly

S van Tol, B Kalveram, PA Ilinykh, A Ronk… - PLoS …, 2022 - journals.plos.org
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging,
viral polymerase function, and host immune antagonism. The mechanisms regulating …

[HTML][HTML] Ebola virus VP35 perturbs type I interferon signaling to facilitate viral replication

Z Cao, C Liu, C Peng, Y Ran, Y Yao, G Xiao, E Li… - Virologica Sinica, 2023 - Elsevier
As one of the deadliest viruses, Ebola virus (EBOV) causes lethal hemorrhagic fevers in
humans and nonhuman primates. The suppression of innate immunity leads to robust …

Contribution of Sec61α to the life cycle of Ebola virus

A Iwasa, P Halfmann, T Noda, M Oyama… - The Journal of …, 2011 - academic.oup.com
Background. Similar to other viruses, the viral proteins of Ebola virus (EBOV) interact with a
variety of host proteins for its replication. Of the 7 structural proteins encoded in the EBOV …

TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction

RP Galão, H Wilson, KL Schierhorn, F Debeljak… - PLoS …, 2022 - journals.plos.org
Ebola virus (EBOV) causes highly pathogenic disease in primates. Through screening a
library of human interferon-stimulated genes (ISGs), we identified TRIM25 as a potent …

Ebolavirus species-specific interferon antagonism mediated by VP24

P Ramanathan, B Tigabu, RI Santos, PA Ilinykh… - Viruses, 2023 - mdpi.com
Members of the Ebolavirus genus demonstrate a marked differences in pathogenicity in
humans with Ebola (EBOV) being the most pathogenic, Bundibugyo (BDBV) less …

New targets for controlling Ebola virus disease

FXF Qin, CY Jiang, T Jiang, G Cheng - National science review, 2015 - academic.oup.com
EBOV infects multiple different cell types and replicates rapidly in vivo [1]. Due to its long
filamentous structure, EBOV is internalized by macropinocytosis after cell surface receptor …