Pre-erythrocytic malaria vaccines: RTS, S, R21, and beyond

EA Hammershaimb, AA Berry - Expert Review of Vaccines, 2024 - Taylor & Francis
Malaria is one of the oldest known human diseases, and the Plasmodium genus of parasites
has plagued vertebrates for millions of years. Although five Plasmodium species infect …

[HTML][HTML] RTS, S: Toward a first landmark on the Malaria Vaccine Technology Roadmap

DC Kaslow, S Biernaux - Vaccine, 2015 - Elsevier
Abstract The Malaria Vaccine Technology Roadmap calls for a 2015 landmark goal of a first-
generation malaria vaccine that has protective efficacy against severe disease and death …

Malaria vaccines: where next?

AA Holder - PLoS pathogens, 2009 - journals.plos.org
A malaria vaccine for mass immunization, which could be delivered cheaply and widely and
provide long lasting protection, would have a massive effect on global public health …

Vaccines against malaria

A Ouattara, MB Laurens - Clinical Infectious Diseases, 2015 - academic.oup.com
Despite global efforts to control malaria, the illness remains a significant public health threat.
Currently, there is no licensed vaccine against malaria, but an efficacious vaccine would …

[HTML][HTML] Status of vaccine research and development of vaccines for malaria

AJ Birkett - Vaccine, 2016 - Elsevier
Despite recent progress in reducing deaths attributable to malaria, it continues to claim
approximately 500,000 lives per year and is associated with approximately 200 million …

Malaria vaccines for children: and now there are two

V Moorthy, MJ Hamel, PG Smith - The Lancet, 2024 - thelancet.com
In 2021, nearly half of the world's population lived at risk from malaria, with over 600 000
deaths annually, of which over 95% occur in the WHO African region and 80% of these in …

RTS, S today and tomorrow's science

NN Nkomba, C Cairo, MK Laufer - Cell host & microbe, 2022 - cell.com
The first malaria vaccine has been recently approved for children living in malaria-endemic
areas. While this is long-awaited and welcome news, the modest efficacy of the vaccine …

Advances in malaria vaccine development: report from the 2017 malaria vaccine symposium

CH Coelho, JYA Doritchamou, I Zaidi, PE Duffy - npj Vaccines, 2017 - nature.com
Abstract The Malaria Vaccine Symposium occurred at Johns Hopkins University in
Baltimore, MD, USA on April 25th, 2017, coinciding with World Malaria Day and the WHO …

Malaria vaccines since 2000: progress, priorities, products

PE Duffy, J Patrick Gorres - npj Vaccines, 2020 - nature.com
Malaria vaccine development entered a new era in 2015 when the pre-erythrocytic
Plasmodium falciparum candidate RTS, S was favorably reviewed by the European …

Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Developing an …