Polygenic scores: prediction versus explanation

R Plomin, S Von Stumm - Molecular psychiatry, 2022 - nature.com
During the past decade, polygenic scores have become a fast-growing area of research in
the behavioural sciences. The ability to directly assess people's genetic propensities has …

Genomic prediction of cognitive traits in childhood and adolescence

AG Allegrini, S Selzam, K Rimfeld, S von Stumm… - Molecular …, 2019 - nature.com
Recent advances in genomics are producing powerful DNA predictors of complex traits,
especially cognitive abilities. Here, we leveraged summary statistics from the most recent …

Molecular genetics in psychology and personality neuroscience: On candidate genes, genome wide scans, and new research strategies

C Montag, RP Ebstein, P Jawinski, S Markett - … & Biobehavioral Reviews, 2020 - Elsevier
Despite the substantial heritability estimates for psychological traits, their precise genetic
foundation from a molecular perspective remains elusive. We summarize findings and …

The future of genetics in psychology and psychiatry: Microarrays, genome‐wide association, and non‐coding RNA

R Plomin, OSP Davis - Journal of Child Psychology and …, 2009 - Wiley Online Library
Background: Much of what we thought we knew about genetics needs to be modified in light
of recent discoveries. What are the implications of these advances for identifying genes …

Embracing polygenicity: a review of methods and tools for psychiatric genetics research

RM Maier, PM Visscher, MR Robinson… - Psychological …, 2018 - cambridge.org
The availability of genome-wide genetic data on hundreds of thousands of people has led to
an equally rapid growth in methodologies available to analyse these data. While the …

[HTML][HTML] Polygenic risk scores in psychiatry: Will they be useful for clinicians?

JM Fullerton, JI Nurnberger - F1000Research, 2019 - ncbi.nlm.nih.gov
Major psychiatric disorders are heritable but they are genetically complex. This means that,
with certain exceptions, single gene markers will not be helpful for diagnosis. However, we …

Research review: polygenic methods and their application to psychiatric traits

NR Wray, SH Lee, D Mehta… - Journal of child …, 2014 - Wiley Online Library
Background Despite evidence from twin and family studies for an important contribution of
genetic factors to both childhood and adult onset psychiatric disorders, identifying robustly …

Spurious genetic associations

PF Sullivan - Biological psychiatry, 2007 - Elsevier
BACKGROUND: Genetic association studies are widely used in biomedical research and
yet only a minority of positive findings stand the test of replication. I explored the capacity of …

Behavioral genetic studies of personality: An introduction and review of the results of 50+ years of research

AM Johnson, PA Vernon, AR Feiler - The SAGE handbook of …, 2008 - torrossa.com
One of the longest-standing debates within psychology concerns the extent to which we can
identify biological factors in the prediction of individual differences in personality. Factors …

Multi-polygenic score approach to trait prediction

E Krapohl, H Patel, S Newhouse, CJ Curtis… - Molecular …, 2018 - nature.com
A primary goal of polygenic scores, which aggregate the effects of thousands of trait-
associated DNA variants discovered in genome-wide association studies (GWASs), is to …