Aim This study aimed to evaluate the contribution of biomechanical loading to inflammation‐
induced tissue destruction. Materials and Methods A total of 144 adult Holtzman rats were …

Background: The present study aims to evaluate the effects of orthodontic movement (OM)
on the periodontal tissues of rats with ligature‐induced periodontal disease. Methods: Eighty …

Periodontitis is a widespread oral disease accompanied by uncontrolled inflammation‐
related tissue destruction. Periodontitis is related to various factors. Among them, occlusal …

The present study aimed to investigate the role of orthodontic force in osteogenesis
differentiation, matrix deposition and mineralization in periodontal ligament cells (PDLCs) …

Objectives Mechanical loading is a potential activator of inflammation and able to stimulate
factors for periodontal and alveolar bone destruction. Aim of this study was to investigate the …

Objective To investigate the functional changes of PDL fibroblasts in the presence of
mechanical force, inflammation, or a combination of force and inflammation. Materials and …

Background Appropriate mechanical stimulation is essential for bone homeostasis in
healthy periodontal tissues. While the osteogenesis and osteoclast differentiation of …

Aim: Orthodontic malpractice as well as hyperocclusal forces can aggravate periodontitis-
induced destruction of tooth-supporting tissues, but the underlying mechanisms for the co …

Objectives The aim of this study was to investigate in vitro the effect of clodronate on
interleukin-1ß (IL-1ß)–stimulated human periodontal ligament fibroblasts (HPdLFs) with the …

Applied mechanical loading induces inflammation in the periodontal ligament (PDL).
However, the mechanisms involved in bone deposition at tension sites in an inflammatory …