Gene–environment interactions: early life stress and risk for depressive and anxiety disorders
Rationale Prior reviews have examined how stress, broadly defined, interacts with genetic
diathesis in the pathogenesis of internalizing (ie, depressive and anxiety) disorders. Recent …
diathesis in the pathogenesis of internalizing (ie, depressive and anxiety) disorders. Recent …
Gene–environment interactions and intermediate phenotypes: early trauma and depression
OP Hornung, CM Heim - Frontiers in endocrinology, 2014 - frontiersin.org
This review focuses on current research developments in the study of gene by early life
stress (ELS) interactions and depression. ELS refers to aversive experiences during …
stress (ELS) interactions and depression. ELS refers to aversive experiences during …
Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics
Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …
factor for developing depressive disorders later in life. We here summarize and discuss …
Mechanisms of gene–environment interactions in depression: evidence that genes potentiate multiple sources of adversity
M Wichers, D Schrijvers, N Geschwind… - Psychological …, 2009 - cambridge.org
BackgroundPrevious work suggests that daily life stress-sensitivity may be an intermediary
phenotype associated with both genetic risk for depression and developmental stress …
phenotype associated with both genetic risk for depression and developmental stress …
Prenatal stress and genetic risk: How prenatal stress interacts with genetics to alter risk for psychiatric illness
PW Abbott, SB Gumusoglu, J Bittle… - …, 2018 - Elsevier
Risk for neuropsychiatric disorders is complex and includes an individual's internal genetic
endowment and their environmental experiences and exposures. Embryonic development …
endowment and their environmental experiences and exposures. Embryonic development …
Research review: Gene–environment interaction research in youth depression–a systematic review with recommendations for future research
Background: Depression is a major public health problem among youth, currently estimated
to affect as many as 9% of US children and adolescents. The recognition that both genes …
to affect as many as 9% of US children and adolescents. The recognition that both genes …
The links between stress and depression: psychoneuroendocrinological, genetic, and environmental interactions
GE Tafet, CB Nemeroff - The Journal of neuropsychiatry and …, 2016 - Am Neuropsych Assoc
The role of stress in the origin and development of depression may be conceived as the
result of multiple converging factors, including the chronic effect of environmental stressors …
result of multiple converging factors, including the chronic effect of environmental stressors …
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
C Anacker, KJ O'Donnell… - Dialogues in clinical …, 2014 - Taylor & Francis
We review studies with human and nonhuman species that examine the hypothesis that
epigenetic mechanisms, particularly those affecting the expression of genes implicated in …
epigenetic mechanisms, particularly those affecting the expression of genes implicated in …
A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility
JR Homberg, J Jagiellowicz - Molecular Psychiatry, 2022 - nature.com
Expert opinion remains divided concerning the impact of putative risk factors on vulnerability
to depression and other stress-related disorders. A large body of literature has investigated …
to depression and other stress-related disorders. A large body of literature has investigated …
Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression
Context Genetic moderation of the depression-inducing effects of stressful life events (SLEs)
has been reported, but findings suggest that genes may not moderate the effects of SLEs per …
has been reported, but findings suggest that genes may not moderate the effects of SLEs per …