Diabetic retinopathy (DR) is a common diabetic complication that severely impacts the life
quality of diabetic patients. Recently, cellular senescence in human retinal endothelial cells …

Chronic exposure of retinal endothelium cells to hyperglycemia is the leading cause of
diabetic retinopathy. We evaluated the effect of high glucose concentration on senescence …

Diabetic retinopathy (DR) is an important microvascular complication of diabetes and one of
the leading causes of blindness in developed countries. Two large clinical studies showed …

Context Oxidative injury in a high-glucose (HG) environment may be a mechanism of
diabetic retinopathy (DR) and edaravone can protect retinal ganglion cells by scavenging …

In this study, we found an imbalance between stress‐mediated and survival signaling and
elevated apoptotic markers in retinal pigment epithelium (RPE) from diabetic patients. Since …

Diabetic nephropathy is one of the most important chronic microvascular complications of
diabetes, and its main feature is diabetic glomerulosclerosis. Endothelial sirtuin 1 (SIRT1) …

In the area of drug discovery, repurposing strategies represent an approach to discover new
uses of approved drugs besides their original indications. We used this approach to …

Methylglyoxal, a highly reactive dicarbonyl compound, is increased and accumulated in
patients with diabetic mellitus. Methylglyoxal forms advanced glycation end products (AGE) …

Background. Methylglyoxal and glyoxal, intermediate products of glycation, are known to
accelerate glycation and the formation of advanced glycation endproducts (AGEs). These …

Advanced glycation end-products (AGEs) are considered to play an important role in the
development of retinopathy in diabetes, and are shown to induce retinal vascular changes …