The nucleolus is a stress sensor and compromised nucleolar activity may be considered as
an attractive anticancer strategy. In the present study, the effects of three plant-derived …

Ribosome biogenesis is a vital and highly energy-consuming cellular function occurring
primarily in the nucleolus. Cancer cells have an elevated demand for ribosomes to sustain …

The nucleolus is a dynamic structure that has roles in various physiological and
pathophysiological processes. Perturbations on many aspects of the nucleolar functions are …

Ribosome biogenesis in the nucleolus is an important process that consumes 80% of a cell's
intracellular energy supply. Disruption of this process results in nucleolar stress, triggering …

Cancer cells are characterized by genetic and epigenetic alterations and phytochemicals,
epigenetic modulators, are considered as promising candidates for epigenetic therapy of …

Cell growth demands new protein synthesis, which requires nucleolar ribosomal functions.
Ribosome biogenesis consumes a large proportion of the cell's resources and energy, and …

The nucleolus is a large nuclear membraneless organelle responsible for ribosome
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …

Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

Trichothecene mycotoxins and other protein synthesis inhibitors activate mitogen-activated
protein kinase (MAPKs) via a mechanism that has been termed the “ribotoxic stress …

Abstract N 6-isopentenyladenosine (i 6 A), a naturally occurring modified nucleoside,
inhibits the proliferation of human tumor cell lines in vitro, but its mechanism of action …