[HTML][HTML] Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Z Liu, Y Zhuang, L Fang, C Yuan, X Wang, K Lin - Bioactive Materials, 2023 - Elsevier
Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain
and affects a patient's quality of life. However, currently, there is a lack of effective early …

Extracellular vesicles from mesenchymal stem cells as potential treatments for osteoarthritis

NA Mohd Noor, A Abdullah Nurul… - Cells, 2021 - mdpi.com
Osteoarthritis (OA) is a chronic degenerative disorder of the joint and its prevalence and
severity is increasing owing to ageing of the population. Osteoarthritis is characterized by …

Extracellular vesicles and their potential significance in the pathogenesis and treatment of osteoarthritis

AM Mustonen, P Nieminen - Pharmaceuticals, 2021 - mdpi.com
Osteoarthritis (OA) is a chronic joint disease characterized by inflammation, gradual
destruction of articular cartilage, joint pain, and functional limitations that eventually lead to …

Stem cell-derived extracellular vesicles for treating joint injury and osteoarthritis

JJ Li, E Hosseini-Beheshti, GE Grau, H Zreiqat… - Nanomaterials, 2019 - mdpi.com
Extracellular vesicles (EVs) are nanoscale particles secreted by almost all cell types to
facilitate intercellular communication. Stem cell-derived EVs theoretically have the same …

Mesenchymal stem cell-derived extracellular vesicles for osteoarthritis treatment: extracellular matrix protection, chondrocyte and osteocyte physiology, pain and …

TH Nguyen, CM Duong, XH Nguyen, UTT Than - Cells, 2021 - mdpi.com
Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and
motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells …

Update on the role of extracellular vesicles in rheumatoid arthritis

H Miao, F Wang, S Lin, Z Chen - Expert Reviews in Molecular …, 2022 - cambridge.org
Rheumatoid arthritis (RA) is a heterogeneous autoimmune disorder that leads to severe joint
deformities, negatively affecting the patient's quality of life. Extracellular vesicles (EVs) …

[HTML][HTML] Extracellular vesicles: Potential role in osteoarthritis regenerative medicine

X Wu, Y Wang, Y Xiao, R Crawford, X Mao… - Journal of orthopaedic …, 2020 - Elsevier
Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation,
subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to …

Extracellular vesicles—new tool for joint repair and regeneration

J Malda, J Boere, CHA Van De Lest… - Nature Reviews …, 2016 - nature.com
Cell-derived extracellular vesicles (EVs), present in synovial fluid and cartilage extracellular
matrix (ECM), are involved in joint development and in the regulation of joint homeostasis …

Secretome and extracellular vesicles as new biological therapies for knee osteoarthritis: a systematic review

D D'Arrigo, A Roffi, M Cucchiarini, M Moretti… - Journal of clinical …, 2019 - mdpi.com
Secretome and extracellular vesicles (EVs) are considered a promising option to exploit
mesenchymal stem cells'(MSCs) properties to address knee osteoarthritis (OA). The aim of …

Co-aggregation of MSC/chondrocyte in a dynamic 3D culture elevates the therapeutic effect of secreted extracellular vesicles on osteoarthritis in a rat model

A Esmaeili, S Hosseini, A Kamali, M Hosseinzadeh… - Scientific Reports, 2022 - nature.com
Extracellular vesicles (EVs) have therapeutic effects on osteoarthritis (OA). Some recent
strategies could elevate EV's therapeutic properties including cell aggregation, co-culture …