Host-pathogen interactions between the human innate immune system and Candida albicans—understanding and modeling defense and evasion strategies

S Dühring, S Germerodt, C Skerka, PF Zipfel… - Frontiers in …, 2015 - frontiersin.org
The diploid, polymorphic yeast Candida albicans is one of the most important human
pathogenic fungi. C. albicans can grow, proliferate and coexist as a commensal on or within …

Friend or foe: using systems biology to elucidate interactions between fungi and their hosts

L Rizzetto, D Cavalieri - Trends in microbiology, 2011 - cell.com
Modelling the networks sustaining the fruitful coexistence between fungi and their
mammalian hosts is becoming increasingly important to control emerging fungal pathogens …

Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies

DJ Wooten, JGT Zañudo, D Murrugarra… - PLoS computational …, 2021 - journals.plos.org
Candida albicans, an opportunistic fungal pathogen, is a significant cause of human
infections, particularly in immunocompromised individuals. Phenotypic plasticity between …

Complexity and dynamics of host–fungal interactions

F Cottier, N Pavelka - Immunologic research, 2012 - Springer
Pathologies attributable to fungal infections represent a growing concern in both developed
and developing countries. Initially discovered as opportunistic pathogens of …

Study of Candida albicans and its interactions with the host: a mini review

PW Tsai, YT Chen, PC Hsu, CY Lan - BioMedicine, 2013 - Elsevier
Candida albicans is an important fungal pathogen in humans. The interaction between C.
albicans and its host is dynamic and complex. This pathogen exhibits multifaceted strategies …

Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans

C Komalapriya, D Kaloriti, AT Tillmann, Z Yin… - PLoS …, 2015 - journals.plos.org
The major fungal pathogen of humans, Candida albicans, mounts robust responses to
oxidative stress that are critical for its virulence. These responses counteract the reactive …

Systems biology of fungal infection

F Horn, T Heinekamp, O Kniemeyer… - Frontiers in …, 2012 - frontiersin.org
Elucidation of pathogenicity mechanisms of the most important human-pathogenic fungi,
Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the …

A Virtual Infection Model Quantifies Innate Effector Mechanisms and Candida albicans Immune Escape in Human Blood

K Hünniger, T Lehnert, K Bieber, R Martin… - PLoS computational …, 2014 - journals.plos.org
Candida albicans bloodstream infection is increasingly frequent and can result in
disseminated candidiasis associated with high mortality rates. To analyze the innate …

Candida albicans pathogenesis: fitting within the host-microbe damage response framework

MA Jabra-Rizk, EF Kong, C Tsui, MH Nguyen… - Infection and …, 2016 - Am Soc Microbiol
Historically, the nature and extent of host damage by a microbe were considered highly
dependent on virulence attributes of the microbe. However, it has become clear that disease …

Game theoretical modelling of survival strategies of Candida albicans inside macrophages

S Hummert, C Hummert, A Schröter, B Hube… - Journal of theoretical …, 2010 - Elsevier
The polymorphic fungus Candida albicans can live as an aggressive pathogen that causes
a wide variety of diseases in humans. Host resistance against these infections is mediated …