For years conception of Th2 overbalance during pregnancy has been a paradigm for
immunology of reproduction, while Th1 activity has been presented as unwanted …

The balance between T helpers type 1 (Th1) and type 2 (Th2) is being postulated to regulate
almost any kind of immune response. Thus, we refer to the Th1/Th2 balance in …

Pregnant females are susceptible to intracellular pathogens and are biased towards
humoral rather than cell-mediated immunity. Since 7", 1 cymkines compromise pregnancy …

There is much evidence that cytokines play a very important role in the maintenance of
pregnancy by modulating immune and endocrine systems. Placental tissue produces …

Zenclussen AC, Fest S, Busse P, Joachim R, Klapp BF, Arck PC. Questioning the Th1/Th2
paradigm in reproduction: peripheral levels of IL‐12 are down‐regulated in miscarriage …

Evidence from studies on murine and human pregnancy points to a strong association
between maternal Th2-type immunity and successful pregnancy on the one hand and …

Wegmann et al.(1993) initially proposed that Thl responses are systemically suppressed
during pregnancy, this suppression being accompanied by local expression of Th2 …

Aim: T cells may be classified as T helper type 1 (Th1) cells, which synthesize cytokines
inducing cellular immunity, or T helper type 2 (Th2), which synthesize cytokines inducing …

It is becoming clear that during each developmental stage of pregnancy, different
immunological conditions exist and may even be necessary for success. The widely …

Citation Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T‐cell paradigm
in pregnancy. Am J Reprod Immunol 2010 T‐helper (Th) cells play a central role in …