Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Upon fertilization, drastic chromatin reorganization occurs during preimplantation
development. However, the global chromatin landscape and its molecular dynamics in this …

Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

DNA methylation, chromatin states and their interrelationships represent critical epigenetic
information, but these are largely unknown in human early embryos. Here, we apply single …

INTRODUCTION In recent years, the single-cell genomics field has made incredible
progress toward disentangling the cellular heterogeneity of human tissues. However, the …

In mammals, chromatin organization undergoes drastic reprogramming after fertilization.
However, the three-dimensional structure of chromatin and its reprogramming in …

Chromatin modifications are associated with many aspects of gene expression, yet their role
in cellular transitions during development remains elusive. Here, we use a new approach to …

During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Genome function is dynamically regulated in part by chromatin, which consists of the
histones, non-histone proteins and RNA molecules that package DNA. Studies in …

Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …