Low-dose lactulose as a prebiotic for improved gut health and enhanced mineral absorption

T Karakan, KM Tuohy, G Janssen-van Solingen - Frontiers in Nutrition, 2021 - frontiersin.org
Although medium and high doses of lactulose are used routinely for the treatment of
constipation and hepatic encephalopathy, respectively, a wealth of evidence demonstrates …

Lactulose: Patient-and dose-dependent prebiotic properties in humans

J Ruszkowski, JM Witkowski - Anaerobe, 2019 - Elsevier
Lactulose is a disaccharide used in clinical practice since 1957 and has since been tested in
the treatment of many human disorders, including chronic constipation, hepatic …

Dose-dependent prebiotic effect of lactulose in a computer-controlled in vitro model of the human large intestine

MK Bothe, AJH Maathuis, S Bellmann… - Nutrients, 2017 - mdpi.com
Lactulose, a disaccharide of galactose and fructose, used as a laxative or ammonia-
lowering drug and as a functional food ingredient, enhances growth of Bifidobacterium and …

Lactulose: Properties, techno-functional food applications, and food grade delivery system

M Nooshkam, A Babazadeh, H Jooyandeh - Trends in Food Science & …, 2018 - Elsevier
Background Every year, high volumes of whey are producing by dairy industries, which
require significant capital investments to discard this highly reactive by-product and to …

A human volunteer study to determine the prebiotic effects of lactulose powder on human colonic microbiota

KM Tuohy, CJ Ziemer, A Klinder, Y Knöbel… - Microbial Ecology in …, 2002 - Taylor & Francis
The prebiotic effects of lactulose were monitored in a human feeding study. Prebiotics are
dietary carbohydrates that have a selective microbial metabolism in the gut, directed towards …

Lactulose modulates the structure of gut microbiota and alleviates colitis-associated tumorigenesis

K Hiraishi, F Zhao, LH Kurahara, X Li, T Yamashita… - Nutrients, 2022 - mdpi.com
Lactulose, a galactose-fructose disaccharide, is made from the milk sugar lactose by heating
or isomerization processes. Lactulose is proposed to modulate gut microbiota and thus …

Lactulose, lactic acid bacteria, intestinal microecology and mucosal protection

S Salminen, E Salminen - Scandinavian Journal of …, 1997 - Taylor & Francis
During the fermentation of lactulose, short-chain fatty acids are formed with consequent
lowering of the colon pH and modification of the microflora. Lactulose promotes the growth …

Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57 BL/6J mice

S Zhai, L Zhu, S Qin, L Li - Microbiologyopen, 2018 - Wiley Online Library
Gut microbiota have strong connections with health. Lactulose has been shown to regulate
gut microbiota and benefit host health. In this study, the effect of short‐term (3 week) …

Colonic food: pre-and probiotics

S Bengmark - The American journal of gastroenterology, 2000 - Elsevier
The colonic mucosa is unable to nourish itself from the blood. Instead, its nutritive demand
must be met from the lumen, where different nutrients, short-chain fatty acids, amino acids …

[HTML][HTML] Dietary supplementation with sorbitol results in selective enrichment of lactobacilli in rat intestine

LA Sarmiento-Rubiano, M Zúñiga… - Research in …, 2007 - Elsevier
A potential prebiotic action has been ascribed to sorbitol, but in vivo evidence of this remains
scarce. In the present work, the effect of sorbitol was compared to that of fructo …