[HTML][HTML] Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

S Kang, M Yang, Z Hong, L Zhang, Z Huang… - … Pharmaceutica Sinica B, 2020 - Elsevier
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually
lead to worldwide human infections and deaths. Currently, there is no specific viral protein …

Structures of the SARS‐CoV‐2 nucleocapsid and their perspectives for drug design

Y Peng, N Du, Y Lei, S Dorje, J Qi, T Luo, GF Gao… - The EMBO …, 2020 - embopress.org
Abstract COVID‐19, caused by SARS‐CoV‐2, has resulted in severe and unprecedented
economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major …

[HTML][HTML] Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein

X Luan, X Li, Y Li, G Su, W Yin, Y Jiang, N Xu, F Wang… - Science Bulletin, 2022 - Elsevier
Nucleocapsid (N) protein plays crucial roles in the life cycle of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), including the formation of ribonucleoprotein (RNP) …

Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein

R Zhou, R Zeng, A von Brunn, J Lei - Molecular biomedicine, 2020 - Springer
The newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
resulted in a global human health crisis. The CoV nucleocapsid (N) protein plays essential …

Structural insight into the SARS-CoV-2 nucleocapsid protein C-terminal domain reveals a novel recognition mechanism for viral transcriptional regulatory sequences

M Yang, S He, X Chen, Z Huang, Z Zhou, Z Zhou… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) has caused massive disruptions to society and the
economy, and the transcriptional regulatory mechanisms behind the severe acute …

Structures of SARS-CoV-2 RNA-binding proteins and therapeutic targets

MT Khan, M Irfan, H Ahsan, A Ahmed, AC Kaushik… - Intervirology, 2021 - karger.com
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic
has resulted in thousands of infections and deaths worldwide. Several therapies are …

Architecture and self‐assembly of the SARS‐CoV‐2 nucleocapsid protein

Q Ye, AMV West, S Silletti, KD Corbett - Protein Science, 2020 - Wiley Online Library
The COVID‐2019 pandemic is the most severe acute public health threat of the twenty‐first
century. To properly address this crisis with both robust testing and novel treatments, we …

Computational drug repurposing study of the RNA binding domain of SARS‐CoV‐2 nucleocapsid protein with antiviral agents

G Tatar, E Ozyurt, K Turhan - Biotechnology progress, 2021 - Wiley Online Library
The recent outbreak of coronavirus disease (COVID‐19) in China caused by the severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has led to worldwide human …

The SARS-CoV-2 nucleocapsid protein and its role in viral structure, biological functions, and a potential target for drug or vaccine mitigation

Z Bai, Y Cao, W Liu, J Li - Viruses, 2021 - mdpi.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world
is still expanding. Thus, there is an urgent need to better understand this novel virus and find …

[HTML][HTML] Structural insights into the mechanism of RNA recognition by the N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein

A Khan, MT Khan, S Saleem, M Junaid, A Ali… - Computational and …, 2020 - Elsevier
The emergence of recent SARS-CoV-2 has become a global health issue. This single-
stranded positive-sense RNA virus is continuously spreading with increasing morbidities …