Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management

L Peng, Y Chen, S Shi, H Wen - Stem Cell Research & Therapy, 2022 - Springer
Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent
years, it remains the most common cause of end-stage renal disease. An early diagnosis …

Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy

Y Duan, Q Luo, Y Wang, Y Ma, F Chen, X Zhu… - Journal of biological …, 2020 - ASBMB
Diabetic nephropathy (DN) is a complication of diabetes that is increasing in prevalence in
China. Extracellular vesicles (EVs) carrying microRNAs (miRs) may represent a useful tool …

Urinary exosomal microRNA signatures in nephrotic, biopsy-proven diabetic nephropathy

WC Lee, LC Li, HY Ng, PT Lin, TTY Chiou… - Journal of clinical …, 2020 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD).
Elucidating the mechanisms underlying proteinuria in DKD is crucial because it is a common …

Exosomal microRNA‐16‐5p from human urine‐derived stem cells ameliorates diabetic nephropathy through protection of podocyte

YR Duan, BP Chen, F Chen, SX Yang… - Journal of Cellular …, 2021 - Wiley Online Library
Diabetic nephropathy (DN) remains one of the severe complications associated with
diabetes mellitus. It is worthwhile to uncover the underlying mechanisms of clinical benefits …

Differential expression of urinary exosomal microRNAs miR-21-5p and miR-30b-5p in individuals with diabetic kidney disease

J Zang, AP Maxwell, DA Simpson, GJ McKay - Scientific reports, 2019 - nature.com
Biomarkers for the identification of diabetic kidney disease (DKD) are needed as current
tests lack sensitivity for detecting early kidney damage. MicroRNAs (miRNAs) are short, non …

The circulating exosomal microRNAs related to albuminuria in patients with diabetic nephropathy

H Kim, YU Bae, JS Jeon, H Noh, HK Park… - Journal of translational …, 2019 - Springer
Background Diabetic nephropathy (DN) is associated with high risk of cardiovascular
disease and mortality. Exosomal microRNAs (miRNAs) regulate gene expression in a …

Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Exosomes from mesenchymal stem cells expressing microribonucleic acid-125b inhibit the progression of diabetic nephropathy via the tumour necrosis factor receptor …

X Cai, F Zou, R Xuan, XY Lai - Endocrine Journal, 2021 - jstage.jst.go.jp
Diabetic nephropathy (DN) seriously threatens the health of patients with diabetes.
Moreover, it has been reported that mesenchymal stem cell (MSC)-derived exosomal …

Urinary exosomal microRNAs in incipient diabetic nephropathy

F Barutta, M Tricarico, A Corbelli, L Annaratone… - PloS one, 2013 - journals.plos.org
MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene
expression via suppression of target mRNAs. MiRNAs are present in body fluids in a …

Urinary exosomal microRNA panel unravels novel biomarkers for diagnosis of type 2 diabetic kidney disease

S Eissa, M Matboli, R Aboushahba, MM Bekhet… - Journal of Diabetes and …, 2016 - Elsevier
Background A potential approach adopted in the current study is to design a panel based on
in silico retrieval of novel miRNAs related to diabetic kidney disease and to evaluate its …