The fluoroquinolones, a new class of potent orally absorbed antimicrobial agents, are
reviewed, considering structure, mechanisms of action and resistance, spectrum, variables …

The newer fluoroquinolones are a major advance in antimicrobial chemotherapy. They
inhibit the supercoiling activity of the DNA gyrase enzyme, thus exerting their antibacterial …

This chapter reviews the chemistry, microbiology, pharmacology, and clinical use of the
fluoroquinolone antimicrobial agents. The molecular and clinical problems of bacterial …

The era of quinolone antibiotics began with the serendipitous discovery of the prototype
quinolone antibiotic, nalidixic acid, during the synthesis of the antimalarial agent …

In general, the fluoroquinolones developed over the past few years have greater potency, a
broader spectrum of antimicrobial activity, greater in vitro efficacy against resistant …

The history of the development of the quinolones is described from the first quinolone,
nalidixic acid, via the first 6-fluorinated quinolone norfloxacin, to the latest extended …

The emergence of resistance to fluoroquinolones in virtually all species of bacteria was
recognized soon after the introduction of these compounds for clinical use more than 10 …

BACKGROUND: Premarketing trials showed the fluoroquinolone agents to have a favorable
side-effect profile, with treatment-related adverse events comprising gastrointestinal, central …

THE introduction of fluoroquinolone antimicrobial agents (Fig. 1) into clinical use is an
important recent advance. 1-3 These drugs, also called quinolones, include norfloxacin …

1. DNA Gyrase....................................................................... 2. Topoisomerase 1V.............. 3.
Selectivity for Bacterial Topoisomerases............................................... 4. Mechanisms of …