Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

An individual's susceptibility to atherosclerotic cardiovascular disease is influenced by
numerous clinical and lifestyle factors, motivating the multifaceted approaches currently …

Polygenic risk scores represent a method of aggregating an individual's genetic information,
weighted by associations between genetic variants and disease outcomes identified from …

Polygenic scores quantify inherited risk by integrating information from many common sites
of DNA variation into a single number. Rapid increases in the scale of genetic association …

Genome-wide association studies (GWAS) have identified several genetic variants
associated with coronary heart disease (CHD), and variations in plasma lipoproteins and …

Genetic risk scores are a useful tool for examining the cumulative predictive ability of genetic
variation on cardiovascular disease. Important considerations for creating genetic risk …

Background—Genome-wide association (GWA) platforms have yielded a rapidly increasing
number of new genetic markers. The ability of these markers to improve prediction of …

Over the past decade, substantial progress has been made in the discovery of alleles
contributing to the risk of coronary artery disease. In addition to providing causal insights into …

Background: There is considerable interest in whether genetic data can be used to improve
standard cardiovascular disease risk calculators, as the latter are routinely used in clinical …

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