OBJECTIVE: Postischemic reperfusion of the lung triggers proinflammatory responses that
stimulate injurious neutrophil chemotaxis. We hypothesized that T lymphocytes are recruited …

OBJECTIVE: A central role of macrophages in initiating lung ischemia-reperfusion injury is
emerging. Tumor necrosis factor-α is a proinflammatory cytokine secreted mainly by …

Leukocytes have been implicated in ischemia-reperfusion (IR) injury of the lung, but the
individual role of T cells has not been explored. Recent evidence in mice suggests that T …

Ischemia-reperfusion injury, a form of sterile inflammation, is the leading risk factor for both
short-term mortality following pulmonary transplantation and chronic lung allograft …

In a murine model of lung ischemia-reperfusion injury (IRI), we previously demonstrated that
lymphocytes increase in the alveolar space during the ischemic period. We hypothesized …

Objective: Proinflammatory cytokines are known to play roles in ischemia-reperfusion injury
of the heart, kidney, small bowel, skin, and liver. Little is known about their roles in ischemia …

Using a rat lung model, we sought to characterize the time course for ischemia-reperfusion
injury and the role of neutrophils in the development of injury. Adult male Long-Evans rats …

Background Intercellular signaling plays an important role in the development of lung
ischemia–reperfusion injury. However, the role of specific mediators remains poorly …

Background. Hepatic ischemia/reperfusion injury during both hepatic resection and
transplantation may lead to local and systemic organ dysfunction. Proinflammatory …

BACKGROUND: Lung ischemia-reperfusion injury (LIRI) is postulated to occur biphasically.
Donor pulmonary macrophages mediate early injury, and neutrophil-dependent injury …