In silico models of biomolecular regulation in cancer, annotated with patient-specific gene
expression data, can aid in the development of novel personalized cancer therapeutic …

Drosophila melanogaster (Drosophila) models of cancer are emerging as powerful tools to
investigate the basic mechanisms underlying tumour progression and identify novel …

Background We propose a new approach for designing personalized treatment for
colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with …

The current standard of care for colorectal cancer (CRC) is a combination of
chemotherapeutics, often supplemented with targeted biological drugs. An urgent need …

To improve and focus preclinical testing, we combine tumor models based on a
decellularized tissue matrix with bioinformatics to stratify tumors according to stage-specific …

The multigenic nature of human tumours presents a fundamental challenge for cancer drug
discovery. Here we use Drosophila to generate 32 multigenic models of colon cancer using …

Cancer is a heterogeneous and complex disease and one of the leading causes of death
worldwide. The high tumor heterogeneity between individuals affected by the same cancer …

Colorectal cancer (CRC) is a complex and heterogeneous disease, characterized by dismal
prognosis and low survival rate in the advanced (metastatic) stage. During the last decade …

Background Addition of oxaliplatin to adjuvant 5-FU has significantly improved the disease-
free survival and served as the first line adjuvant chemotherapy in advanced colorectal …

Transcription factors (TFs) are gene regulatory proteins that are essential for an effective
regulation of the transcriptional machinery. Today, it is known that their expression plays an …