[HTML][HTML] Integrated proteogenomic characterization of human high-grade serous ovarian cancer
To provide a detailed analysis of the molecular components and underlying mechanisms
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …
[HTML][HTML] Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status
A cell line representative of human high-grade serous ovarian cancer (HGSOC) should not
only resemble its tumour of origin at the molecular level, but also demonstrate functional …
only resemble its tumour of origin at the molecular level, but also demonstrate functional …
[HTML][HTML] Time to recurrence and survival in serous ovarian tumors predicted from integrated genomic profiles
Background Serous ovarian cancer (SeOvCa) is an aggressive disease with differential and
often inadequate therapeutic outcome after standard treatment. The Cancer Genome Atlas …
often inadequate therapeutic outcome after standard treatment. The Cancer Genome Atlas …
[PDF][PDF] Integrating genomic, epigenomic, and transcriptomic features reveals modular signatures underlying poor prognosis in ovarian cancer
Ovarian cancer has a poor prognosis, with different outcomes for different patients. The
mechanism underlying this poor prognosis and heterogeneity is not well understood. We …
mechanism underlying this poor prognosis and heterogeneity is not well understood. We …
[HTML][HTML] Applications of proteomics in ovarian cancer: dawn of a new era
A Ghose, SVN Gullapalli, N Chohan, A Bolina… - Proteomes, 2022 - mdpi.com
The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …
patients present an advanced stage at diagnosis. This heterogeneous disease has …
[HTML][HTML] Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long-and short-term survivors
Background Patients diagnosed with high-grade serous ovarian cancer (HGSOC) who
received initial debulking surgery followed by platinum-based chemotherapy can …
received initial debulking surgery followed by platinum-based chemotherapy can …
[PDF][PDF] Proteogenomic characterization of ovarian HGSC implicates mitotic kinases, replication stress in observed chromosomal instability
In the absence of a dominant driving mutation other than uniformly present TP53 mutations,
deeper understanding of the biology driving ovarian high-grade serous cancer (HGSC) …
deeper understanding of the biology driving ovarian high-grade serous cancer (HGSC) …
Multiomic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma
Multiple studies have identified transcriptome subtypes of high-grade serous ovarian
carcinoma (HGSOC), but their interpretation and translation are complicated by tumor …
carcinoma (HGSOC), but their interpretation and translation are complicated by tumor …
[HTML][HTML] Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer
B Győrffy - Geroscience, 2023 - Springer
Progress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually
at an advanced stage, there is a high demand for reliable prognostic biomarkers capable of …
at an advanced stage, there is a high demand for reliable prognostic biomarkers capable of …
Single‐cell transcriptomes reveal heterogeneity of high‐grade serous ovarian carcinoma
Q Hao, J Li, Q Zhang, F Xu, B Xie, H Lu… - Clinical and …, 2021 - Wiley Online Library
Background High‐grade serous ovarian carcinoma (HGSOC) is the most common and
aggressive histotype of epithelial ovarian cancer. The heterogeneity and molecular basis of …
aggressive histotype of epithelial ovarian cancer. The heterogeneity and molecular basis of …