Arachidonic acid is one of the most abundant and ubiquitous ω-6 polyunsaturated fatty acid,
present in esterified form in the membrane phospholipids of all mammalian cells and …

Current understanding of the mechanisms underlying plaque development (1-3) assigns a
key role to oxidative modifications of specific phospholipids that are carried into the …

Inhibition of platelet cyclooxygenase (COX)-1 is involved in aspirin cardioprotection
observed in clinical trials, but, in some patients, aspirin is unable to protect from thrombotic …

The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Prostacyclin (PGI2) is the major product of COX-catalyzed metabolism of arachidonic acid in
human macrovascular endothelium. 1 Cultured human endothelial cells synthesize PGI2 (≈ …

follows activation of the enzyme phospholipase A2. On release, arachidonic acid is rapidly
metabolized by prostaglandin (PG) H2 synthase, also known as cyclooxygenase (COX) …

Since the discovery of the pivotal role of cyclooxygenase (COX) in the metabolism of
arachidonic acid, vascular biologists have been confronted with the duality of this system …

Eicosanoids are biologically active lipids in both physiologic and pathophysiologic
situations. These mediators rapidly generate at sites of inflammation and act through specific …

Eicosanoids are bioactive, oxygenated polyunsaturated fatty acids (FAs) derived from the
nutritionally essential 20 carbon fatty acid, arachidonic acid (AA). Oxidation of other …

We investigated whether biologically relevant concentrations of the mono-
hydroxyeicosatetraenoic acids (mono-HETEs) modulate platelet functions. We report that 15 …