Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive
immunity, and increased inflammation and myeloid pathologies,. Age-related changes in …

The extensive self-renewal capacity of hematopoietic stem cells (HSCs) implies that this cell
population may not age and thus may provide undiminished replenishment of blood cells …

Whether hematopoietic stem cells (HSCs) change with aging has been controversial.
Previously, we showed that the HSC compartment in young mice consists of distinct subsets …

Aging-associated remodeling of the immune system impairs its functional integrity and
contributes to increased morbidity and mortality in the elderly. Aging of hematopoietic stem …

Current models propose that reductions in the number of lymphoid-biased hematopoietic
stem cells (Ly-HSCs) underlie age-related declines in lymphopoiesis. We show that Ly …

Genetic defects that accumulate in haematopoietic stem cells (HSCs) are thought to be
responsible for age-related changes in haematopoiesis that include a decline in …

Ageing in multicellular organisms typically involves a progressive decline in cell
replacement and repair processes, resulting in several physiological deficiencies, including …

Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …

Aging is associated with an inability to mount protective antibody responses to vaccines and
infectious agents. This decline is associated with acquisition of defects in multiple cellular …

We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and
compared their properties to HSCs in young and middle–aged mice. Single, reconstituting …