[HTML][HTML] Paving the way for small-molecule drug discovery

YS Ma, R Xin, XL Yang, Y Shi, DD Zhang… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Small-molecule drugs are organic compounds affecting molecular pathways by targeting
important proteins, which have a low molecular weight, making them penetrate cells easily …

Integration of small‐molecule discovery in academic biomedical research

M Ohlmeyer, MM Zhou - Mount Sinai Journal of Medicine: A …, 2010 - Wiley Online Library
Rapid advances in biomedical sciences in recent years have drastically accelerated the
discovery of the molecular basis of human diseases. The great challenge is how to translate …

[引用][C] Recent advances on small molecule medicinal chemistry to treat human diseases

DK Yadav - Current topics in medicinal chemistry, 2021 - ingentaconnect.com
Medicinal Chemistry, in particular the small molecules-based drug discovery, is a
challenging, strategic, and scientific key for augmenting the chemical facets of drug …

Novel small molecules in targeted cancer therapy

R Li, XL Ma, C Gou, WKF Tse - Frontiers in Pharmacology, 2023 - frontiersin.org
Over the last few decades, small molecule cancer drug discovery and development have
focused on personalized medicine, emphasizing molecularly targeted drugs. Because of …

Discovery of innovative small molecule therapeutics

M Abou-Gharbia - Journal of Medicinal Chemistry, 2009 - ACS Publications
I'm honored and privileged to receive the prestigious Alfred Burger Award in Medicinal
Chemistry and to join the list of distinguished individuals who received this honor before me …

Leveraging the attributes of biologics and small molecules, and releasing the bottlenecks: a new wave of revolution in drug development

C Oo, SS Kalbag - Expert review of clinical pharmacology, 2016 - Taylor & Francis
Having a sound strategy is obligatory to success, and the starting point is to have a noble
goal in mind. Without doubt, one of our universal goals is to alleviate human illnesses …

Application of chemical biology in target identification and drug discovery

Y Zhu, T Xiao, S Lei, F Zhou, MW Wang - Archives of pharmacal research, 2015 - Springer
Drug discovery and development is vital to the well-being of mankind and sustainability of
the pharmaceutical industry. Using chemical biology approaches to discover drug leads has …

Advancing new chemical modalities into clinical studies

MJ Blanco, KM Gardinier… - ACS Medicinal Chemistry …, 2022 - ACS Publications
Drug discovery and development has experienced an incredible paradigm shift in the past
two decades. What once was considered a predominant R&D landscape of small molecules …

Medicinal chemistry matters–a call for discipline in our discipline

C Johnstone - Drug discovery today, 2012 - Elsevier
Medicinal chemistry makes a vital contribution to small molecule drug discovery, and the
quality of it contributes directly to research effectiveness as well as to downstream costs …

Building a pharmacological lexicon: small molecule discovery in academia

JS Lazo, LS Brady, R Dingledine - Molecular pharmacology, 2007 - ASPET
Small molecules are powerful pharmacological tools to dissect biological events. There is
now considerable interest in expanding efforts to identify and use small molecules targeting …