Heart failure with preserved ejection fraction (HFpEF) is associated with exercise intolerance
due to alterations in the skeletal muscle (SKM). Leucine supplementation is known to alter …

Leucine supplementation potentiates the effects of aerobic exercise training (AET) on
skeletal muscle; however, its potential effects associated with AET on cardiac muscle have …

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome associated
with a high morbidity and mortality rate. Leucine supplementation has been demonstrated to …

Background Protein-energy malnutrition (PEM) can lead to growth hormone (GH) resistance.
Leucine supplementation diets have been shown to increase protein synthesis in muscles …

Aims Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance
(ie breathlessness and fatigue) in heart failure patients with preserved ejection fraction …

Leucine is an essential amino acid that has been investigated by its participation in the
regulation of whole-body metabolism and mitochondrial function. Here, we evaluated acute …

Many forms of cancer are associated with loss of lean body mass, commonly attributed to
decreased protein synthesis and stimulation of proteolytic pathways within the skeletal …

Leucine acts as a signal nutrient in promoting protein synthesis in skeletal muscle and
adipose tissue via mTOR pathway activation, and may be of interest in age-related …

Background The condition known as cachexia presents in most patients with malignant
tumours, leading to a poor quality of life and premature death. Although the cancer‐cachexia …

Abstract Fibroblast growth factor 21 (FGF21) is a growth factor with pleiotropic effects on
regulating lipid and glucose metabolism. Its expression is increased in skeletal muscle of …