Experimental models to study immune dysfunction in the pathogenesis of Parkinson's disease

J Saponjic, R Mejías, N Nikolovski, M Dragic… - International journal of …, 2024 - mdpi.com
Parkinson's disease (PD) is a chronic, age-related, progressive multisystem disease
associated with neuroinflammation and immune dysfunction. This review discusses the …

Immune responses in Parkinson's disease: interplay between central and peripheral immune systems

X Su, HJ Federoff - BioMed research international, 2014 - Wiley Online Library
The etiology of Parkinson's disease (PD) is complex and most likely involves numerous
environmental and heritable risk factors. Recent studies establish that central and peripheral …

The role of innate immunity and inflammation in Parkinson s disease

M Öberg, I Fabrik, D Fabrikova… - Scandinavian …, 2021 - Wiley Online Library
For many years, it was postulated that the brain is the organ behind the barrier with an
autonomous need for its maintenance. This view has been changed by the concept that the …

The immune system in Parkinson's disease: what we know so far

C Roodveldt, L Bernardino, O Oztop-Cakmak, M Dragic… - Brain, 2024 - academic.oup.com
Parkinson's disease (PD) is characterised neuropathologically by the degeneration of
dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) …

Peripheral-central neuroimmune crosstalk in Parkinson's disease: what do patients and animal models tell us?

MT Fuzzati-Armentero, S Cerri, F Blandini - Frontiers in neurology, 2019 - frontiersin.org
The brain is no longer considered an immune privileged organ and neuroinflammation has
long been associated with Parkinson's disease. Accumulating evidence demonstrates that …

Evidence of inflammatory system involvement in Parkinson's disease

Y Chao, SC Wong, EK Tan - BioMed research international, 2014 - Wiley Online Library
Parkinson's disease (PD) is a chronic neurodegenerative disease underpinned by both
genetic and environmental etiologic factors. Recent findings suggest that inflammation may …

Parkinson disease and the immune system—associations, mechanisms and therapeutics

EK Tan, YX Chao, A West, LL Chan, W Poewe… - Nature Reviews …, 2020 - nature.com
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …

The role of immune dysfunction in Parkinson's disease Development

D Cossu, T Hatano, N Hattori - International Journal of Molecular …, 2023 - mdpi.com
Recent research has unveiled intriguing insights suggesting that the body's immune system
may be implicated in Parkinson's disease (PD) development. Studies have observed …

Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

Disease mechanisms as subtypes: Inflammation in Parkinson disease and related disorders

DG Standaert, AS Harms, GM Childers… - Handbook of Clinical …, 2023 - Elsevier
Neuroinflammation is a core feature of Parkinson disease (PD) and related disorders.
Inflammation is detectable early in PD and persists throughout the disease state. Both the …