MicroRNAs in epilepsy: pathophysiology and clinical utility

DC Henshall, HM Hamer, RJ Pasterkamp… - The Lancet …, 2016 - thelancet.com
Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …

MicroRNA and epilepsy: profiling, functions and potential clinical applications

DC Henshall - Current opinion in neurology, 2014 - journals.lww.com
MicroRNA and epilepsy: profiling, functions and potential cl... : Current Opinion in Neurology
MicroRNA and epilepsy: profiling, functions and potential clinical applications : Current …

microRNA and epilepsy

CR Reschke, DC Henshall - … Medical Evidence: From Molecular Biology to …, 2015 - Springer
Epilepsy is a common, serious neurological disease characterized by recurring seizures.
Such abnormal, excessive synchronous firing of neurons arises in part because of …

The challenge of microRNA as a biomarker of epilepsy

Y Ma - Current Neuropharmacology, 2018 - ingentaconnect.com
Background: Epilepsy is one of chronic severe neurological disorders possess to recurring
seizures. And now anti-epileptic drugs are only effective in less than one third of epilepsy …

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

EM Jimenez-Mateos, T Engel, P Merino-Serrais… - Nature medicine, 2012 - nature.com
Temporal lobe epilepsy is a common, chronic neurological disorder characterized by
recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that …

[HTML][HTML] MicroRNA dysregulation in epilepsy: from pathogenetic involvement to diagnostic biomarker and therapeutic agent development

J Wang, J Zhao - Frontiers in molecular neuroscience, 2021 - frontiersin.org
Epilepsy is the result of a group of transient abnormalities in brain function caused by an
abnormal, highly synchronized discharge of brain neurons. MicroRNA (miRNA) is a class of …

MicroRNAs as regulators of brain function and targets for treatment of epilepsy

GP Brennan, DC Henshall - Nature Reviews Neurology, 2020 - nature.com
Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

Epilepsy and microRNA

EM Jimenez-Mateos, DC Henshall - Neuroscience, 2013 - Elsevier
MicroRNA (miRNA) is a class of small non-coding RNA which regulates post-transcriptional
gene expression by repressing and thereby fine-tuning protein production, mainly via …

[HTML][HTML] MicroRNAs in the pathophysiology and treatment of status epilepticus

DC Henshall - Frontiers in molecular neuroscience, 2013 - frontiersin.org
MicroRNA (miRNA) are an important class of non-coding RNA which function as post-
transcriptional regulators of gene expression in cells, repressing and fine-tuning protein …

Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy

JA Gorter, A Iyer, I White, A Colzi, EA van Vliet… - Neurobiology of …, 2014 - Elsevier
Since aberrant miRNA expression has been implicated in numerous brain diseases, we
studied miRNA expression and miRNA regulation of important signaling pathways during …