[HTML][HTML] Activation of SIRT-1 pathway by nanoceria sheds light on its ameliorative effect on doxorubicin-induced cognitive impairment (chemobrain): Restraining its …

M Taha, ST Elazab, AM Badawy, AA Saati, NF Qusty… - Pharmaceuticals, 2022 - mdpi.com
Chemo fog is one of the most serious health concerns encountered by cancer survivors
receiving doxorubicin (DOX)-based chemotherapy. Oxidative stress, neuroinflammation …

Nanoceria restrains PM2. 5-induced metabolic disorder and hypothalamus inflammation by inhibition of astrocytes activation related NF-κB pathway in Nrf2 deficient …

MX Xu, YF Zhu, HF Chang, Y Liang - Free Radical Biology and Medicine, 2016 - Elsevier
Increasing studies demonstrated that air pollution (PM2. 5) plays a significant role in
metabolic and neurological diseases. Unfortunately, there is no direct testimony of this, and …

Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell …

X Liu, M Tang, TY He, S Zhao, HZ Li, Z Li… - Drug Design …, 2023 - Taylor & Francis
Objective This study aimed to investigate the effect of resveratrol (Res) on paclitaxel (PTX)-
induced cognitive impairment and elucidate the underlying molecular mechanisms. Methods …

[HTML][HTML] Diosmin alleviates doxorubicin-induced chemobrain in rats via inhibition of oxido-inflammation, apoptosis and modulation of autophagy

OO Mega, FY Faith, OP Ejiro, JG Uchechukwu… - Brain Disorders, 2024 - Elsevier
Background/aim Doxorubicin (DOX) is a highly effective chemotherapy medicine commonly
used to treat breast cancer; yet, despite its clinical efficacy, it usually causes chemobrain. As …

[HTML][HTML] Donepezil protects against doxorubicin-induced chemobrain in rats via attenuation of inflammation and oxidative stress without interfering with doxorubicin …

B Ongnok, T Khuanjing, T Chunchai, P Pantiya… - …, 2021 - Elsevier
Although doxorubicin (Dox) is an effective chemotherapy medication used extensively in the
treatment of breast cancer, it frequently causes debilitating neurological deficits known as …

Dexmedetomidine attenuates cisplatin-induced cognitive impairment by modulating miR-429-3p expression in rats

C Li, J Niu, B Zhou, W Deng, F Deng, Z Zhou, G Xu - 3 Biotech, 2020 - Springer
Chemotherapy-induced cognitive impairment (CICI) is widely recognized as a frequent
adverse side effect following the administration of chemotherapeutic agents. This study …

[HTML][HTML] Piracetam as a therapeutic agent for doxorubicin-induced cognitive deficits by enhancing cholinergic functions and reducing neuronal inflammation, apoptosis …

V Mani, SI Rabbani, A Shariq, P Amirthalingam… - Pharmaceuticals, 2022 - mdpi.com
Cancer chemotherapy is known to cause cognitive defects in patients. Our study
investigated the effect of piracetam (PIRA; 200 or 400 mg/kg) against doxorubicin (DOX) …

Neuroprotective efficiency of prodigiosins conjugated with selenium nanoparticles in rats exposed to chronic unpredictable mild stress is mediated through …

A Albrakati, KF Alsharif, NE Al Omairi… - International Journal …, 2021 - Taylor & Francis
Purpose Depression is a mood disorder accompanied by intensive molecular and
neurochemical alterations. Currently, available antidepressant therapies are not fully …

Calmodulin inhibitor ameliorates cognitive dysfunction via inhibiting nitrosative stress and NLRP 3 signaling in mice with bilateral carotid artery stenosis

R Wang, YX Yin, Q Mahmood, XJ Wang… - CNS neuroscience & …, 2017 - Wiley Online Library
Summary Aims Vascular dementia (VaD) is a heterogeneous brain disorder for which there
are no effective approved pharmacological treatments available. We aimed to evaluate the …

[HTML][HTML] Levetiracetam ameliorates doxorubicin-induced chemobrain by enhancing cholinergic transmission and reducing neuroinflammation using an experimental …

V Mani, M Arfeen, SI Rabbani, A Shariq… - Molecules, 2022 - mdpi.com
Cancer chemotherapy-induced cognitive impairment (chemobrain) is a major complication
that affects the prognosis of therapy. Our study evaluates the nootropic-like activity of …