[HTML][HTML] Striatins and STRIPAK complex partners in clinical outcomes of patients with breast cancer and responses to drug treatment

AX Li, JJ Zeng, TA Martin, L Ye, F Ruge… - Chinese Journal of …, 2023 - ncbi.nlm.nih.gov
Objective Striatins (STRNs) family, which contains three multi-domain scaffolding proteins,
are cornerstones of the striatins interacting phosphatase and kinase (STRIPAK) complex …

Cellular impacts of striatins and the STRIPAK complex and their roles in the development and metastasis in clinical cancers

AX Li, TA Martin, J Lane, WG Jiang - Cancers, 2023 - mdpi.com
Simple Summary The STRIPAK (striatin-interacting phosphatase and kinase) complex and
its central components, striatins (STRNs), have attracted significant interest with regard to …

The dysregulation and prognostic analysis of STRIPAK complex across cancers

R Xie, F Wen, Y Qin - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
The striatin-interacting phosphatase and kinase (STRIPAK) is the highly conserved complex,
which gains increased attention in physiology and pathology process recently. However …

STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent

X Zhang, Q Chen, Y He, Q Shi, C Yin, Y Xie… - Journal of Experimental …, 2023 - Springer
Background Striatin interacting protein 2 (STRIP2) is a core component of the striatin-
interacting phosphatase and kinase (STRIPAK) complexes, which is involved in tumor …

Silencing of STRN 4 suppresses the malignant characteristics of cancer cells

M Wong, T Hyodo, E Asano, K Funasaka… - Cancer …, 2014 - Wiley Online Library
The striatin family of proteins, comprising STRN, STRN 3 and STRN 4, are multidomain‐
containing proteins that associate with additional proteins to form a large protein complex …

Altered expression of striatin‑4 is associated with poor prognosis in bladder transitional cell carcinoma

Y Zhang, X Gu, F Jiang, P Sun, X Li - Oncology Letters, 2021 - spandidos-publications.com
Abstract Striatin‑4 (STRN4 or Zinedin) is a scaffolding protein belonging to the mammalian
STRN family of proteins and consists of multiple functional signaling domains. Due to its …

STRIP2, a member of the striatin‐interacting phosphatase and kinase complex, is implicated in lung adenocarcinoma cell growth and migration

LM Qiu, YH Sun, TT Chen, JJ Chen, HT Ma - FEBS Open Bio, 2020 - Wiley Online Library
Lung adenocarcinoma (LUAD) accounts for~ 40% of lung cancer cases, and the 5‐year
relative survival rate is no more than 1%. Dysregulation of components of striatin‐interacting …

[HTML][HTML] SPARC overexpression in primary tumors correlates with disease recurrence and overall survival in patients with triple negative breast cancer

A Zhu, P Yuan, F Du, R Hong, X Ding, X Shi, Y Fan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
SPARC/osteonectin expression is reportedly altered in various malignancies. However, little
is known regarding to the prognostic value of SPARC in triple-negative breast cancer …

The profile of expression of the scaffold protein SG2NA (s) differs between cancer types and its interactome in normal vis-a-vis breast tumor tissues suggests its wide …

P Bisoyi, P Devi, K Besra, A Prasad, BP Jain… - Molecular and Cellular …, 2022 - Springer
Striatin and SG2NA are scaffold proteins that form signaling complexes called STRIPAK. It
has been associated with developmental abnormalities, cancer, and several other diseases …

SPARC in cancer‐associated fibroblasts is an independent poor prognostic factor in non‐metastatic triple‐negative breast cancer and exhibits pro‐tumor activity

LB Alcaraz, A Mallavialle, C Mollevi… - … Journal of Cancer, 2023 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is the most aggressive breast cancer subtype and
lacks specific targeted therapeutic agents. The current mechanistic evidence from cell …