Single-cell whole-genome sequencing methods have undergone great improvements over
the past decade. However, allele dropout, which means the inability to detect both alleles …

Abstract We developed “sci-LIANTI”, a high-throughput, high-coverage single-cell DNA
sequencing method that combines single-cell combinatorial indexing (“sci”) and linear …

Meiotic recombination rates vary across the genome, often involving localized crossover
hotspots and coldspots. Studying the molecular basis and mechanisms underlying this …

Motivation Meiotic recombination facilitates the transmission of exchanged genetic material
between homologous chromosomes and plays a crucial role in increasing the genetic …

Conventional methods for single-cell genome sequencing are limited with respect to
uniformity and throughput. Here, we describe sci-L3, a single-cell sequencing method that …

Meiotic DNA double-stranded breaks (DSBs) initiate genetic recombination in discrete areas
of the genome called recombination hotspots. DSBs can be directly mapped using …

Meiotic recombination creates genetic diversity and ensures segregation of homologous
chromosomes. Previous population analyses yielded results averaged among individuals …

Recombination plays a crucial role in meiosis, ensuring the proper segregation of
chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that …

Meiosis is a cellular division process that produces gametes for sexual reproduction.
Disruption of complex events throughout meiosis, such as synapsis and homologous …

INTRODUCTION In diploid organisms, the two chromosomes in each homologous pair act
independently of each other during most cellular functions. An exception occurs in meiosis …