SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

D Mannar, JW Saville, X Zhu, SS Srivastava… - Science, 2022 - science.org
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo …

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody

W Yin, Y Xu, P Xu, X Cao, C Wu, C Gu, X He, X Wang… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has
become the dominant infective strain. We report the structures of the Omicron spike trimer on …

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

M McCallum, N Czudnochowski, LE Rosen, SK Zepeda… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern evades antibody-mediated immunity that comes from vaccination or infection with …

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

X Zhu, D Mannar, SS Srivastava, AM Berezuk… - PLoS …, 2021 - journals.plos.org
The recently reported “UK variant”(B. 1.1. 7) of SARS-CoV-2 is thought to be more infectious
than previously circulating strains as a result of several changes, including the N501Y …

Structural basis for human receptor recognition by SARS-CoV-2 Omicron variant BA. 1

Q Geng, K Shi, G Ye, W Zhang, H Aihara, F Li - Journal of Virology, 2022 - Am Soc Microbiol
The highly contagious and fast-spreading omicron variant of SARS-CoV-2 infects the
respiratory tracts efficiently. The receptor-binding domain (RBD) of the omicron spike protein …

Structures of Omicron spike complexes and implications for neutralizing antibody development

H Guo, Y Gao, T Li, T Li, Y Lu, L Zheng, Y Liu, T Yang… - Cell reports, 2022 - cell.com
The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries
worldwide. The high number of spike mutations is responsible for the broad immune evasion …

[HTML][HTML] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant

L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
Summary The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

Y Cai, J Zhang, T Xiao, CL Lavine, S Rawson, H Peng… - Science, 2021 - science.org
Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) have become the dominant circulating strains in the COVID-19 pandemic. We report …

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

KK Chan, D Dorosky, P Sharma, SA Abbasi, JM Dye… - Science, 2020 - science.org
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble …

Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice

S Liu, P Selvaraj, K Sangare, B Luan, TT Wang - Cell Reports, 2022 - cell.com
Despite being more transmissible, the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) Omicron variant only causes milder diseases in laboratory animals, often …