Nirmatrelvir and the risk of post-acute sequelae of COVID-19

Y Xie, T Choi, Z Al-Aly - MedRxiv, 2022 - medrxiv.org
Long Covid–the disease encompassing the post-acute sequelae of SARS-CoV-2 (PASC)—
affects millions of people around the world. Prevention of PASC is an urgent public health …

Association of treatment with nirmatrelvir and the risk of post–COVID-19 condition

Y Xie, T Choi, Z Al-Aly - JAMA Internal Medicine, 2023 - jamanetwork.com
Importance Post–COVID-19 condition (PCC), also known as long COVID, affects many
individuals. Prevention of PCC is an urgent public health priority. Objective To examine …

Association of nirmatrelvir for acute SARS‐CoV‐2 infection with subsequent Long COVID symptoms in an observational cohort study

MS Durstenfeld, MJ Peluso, F Lin… - Journal of Medical …, 2024 - Wiley Online Library
Oral nirmatrelvir/ritonavir is approved as treatment for acute COVID‐19, but the effect of
treatment during acute infection on risk of Long COVID is unknown. We hypothesized that …

Efficacy of nirmatrelvir and ritonavir for post‐acute COVID‐19 sequelae beyond 3 months of SARS‐CoV‐2 infection

MH Chuang, JY Wu, TH Liu, WH Hsu… - Journal of Medical …, 2023 - Wiley Online Library
The effect of nirmatrelvir plus ritonavir (NMV‐r) on post‐acute COVID‐19 sequelae beyond 3
months of SARS‐CoV‐2 infection remains unknown. This retrospective cohort study utilized …

Nirmatrelvir/ritonavir and risk of long COVID symptoms: a retrospective cohort study

S Congdon, Z Narrowe, N Yone, J Gunn, Y Deng… - Scientific reports, 2023 - nature.com
We conducted a retrospective cohort study to assess whether treatment with
nirmatrelvir/ritonavir was associated with a reduced risk of long COVID. We enrolled 500 …

Nirmatrelvir-ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to COVID-19 complications

CR Dormuth, JD Kim, A Fisher, J Piszczek… - JAMA network …, 2023 - jamanetwork.com
Importance Postmarket analysis of individuals who receive nirmatrelvir and ritonavir
(Paxlovid [Pfizer]) is essential because they differ substantially from individuals included in …

[HTML][HTML] Effect of oral nirmatrelvir on long COVID symptoms: 4 cases and rationale for systematic studies

MJ Peluso, K Anglin, MS Durstenfeld… - Pathogens and …, 2022 - ncbi.nlm.nih.gov
Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and
treatment on the development and persistence of Long COVID have intensified. Methods …

Nirmatrelvir use and severe Covid-19 outcomes during the Omicron surge

R Arbel, Y Wolff Sagy, M Hoshen, E Battat… - … England Journal of …, 2022 - Mass Medical Soc
Background The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-
risk, unvaccinated patients infected with the B. 1.617. 2 (delta) variant of severe acute …

Association of nirmatrelvir–ritonavir with post-acute sequelae and mortality in patients admitted to hospital with COVID-19: a retrospective cohort study

H Wang, Y Wei, CT Hung, G Lin, X Jiang… - The Lancet Infectious …, 2024 - thelancet.com
Background Studies have established the short-term efficacy of nirmatrelvir–ritonavir in
managing COVID-19, yet its effect on post-COVID-19 condition, especially in patients …

Oral nirmatrelvir for high-risk, nonhospitalized adults with Covid-19

J Hammond, H Leister-Tebbe, A Gardner… - … England Journal of …, 2022 - Mass Medical Soc
Background Nirmatrelvir is an orally administered severe acute respiratory syndrome
coronavirus 2 main protease (Mpro) inhibitor with potent pan–human-coronavirus activity in …