Animals respond to chronic hypoxia by increasing the levels of a transcription factor known
as the hypoxia‐inducible factor (HIF). HIF upregulates multiple genes, the products of which …

The hypoxia-inducible factor (HIF) system orchestrates cellular responses to hypoxia in
animals. HIF is an α/β-heterodimeric transcription factor that regulates the expression of …

Oxygen (O 2) is an essential nutrient that serves as a key substrate in cellular metabolism
and bioenergetics. In a variety of physiological and pathological states, organisms …

The hypoxia-inducible transcription factors (HIFs) are central components in the cellular
responses to a lack of O2, ie hypoxia. Homologs of the HIF system (HIF-1,-2 and-3) are …

Sensing and responding to fluxes in oxygen tension is perhaps the single most important
variable in physiology, and animal tissues have developed a number of essential …

Animals respond to the challenge of limited oxygen availability by a coordinated response
that works to increase oxygen supply and minimize tissue damage. The chronic hypoxic …

Abstract Hypoxia-inducible factor-1 (HIF-1) has a central role in the mammalian program by
which cells respond to hypoxia in both physiological and pathological situations. HIF-1 …

Hypoxia, a reduction in partial oxygen pressure, is a salient property of solid tumors.
Hypoxia drives malignant progression and metastasis in tumors and participates in tumor …

The hypoxia-inducible factor (HIF) family of transcription factors is responsible for
coordinating the cellular response to low oxygen levels in animals. By regulating the …

Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …