Global positioning system: understanding long noncoding RNAs through subcellular localization

J Carlevaro-Fita, R Johnson - Molecular cell, 2019 - cell.com
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary
determinant of their molecular functions. LncRNAs are often thought of as chromatin …

Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution

MN Cabili, MC Dunagin, PD McClanahan, A Biaesch… - Genome biology, 2015 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) have been implicated in diverse
biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far …

LncATLAS database for subcellular localization of long noncoding RNAs

D Mas-Ponte, J Carlevaro-Fita, E Palumbo, TH Pulido… - Rna, 2017 - rnajournal.cshlp.org
The subcellular localization of long noncoding RNAs (lncRNAs) holds valuable clues to their
molecular function. However, measuring localization of newly discovered lncRNAs involves …

Long noncoding RNAs in cell biology

MB Clark, JS Mattick - Seminars in cell & developmental biology, 2011 - Elsevier
Whole genome transcriptomic analyses have identified large numbers of dynamically
expressed long non-protein-coding RNAs (lncRNAs) in mammals and other animals whose …

Long noncoding RNAs: an emerging link between gene regulation and nuclear organization

S Quinodoz, M Guttman - Trends in cell biology, 2014 - cell.com
Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play
important roles in diverse biological processes. As a class, lncRNAs are generally enriched …

Chromatin and RNA maps reveal regulatory long noncoding RNAs in mouse

GK Bogu, P Vizán, LW Stanton, M Beato… - … and cellular biology, 2016 - Taylor & Francis
Discovering and classifying long noncoding RNAs (lncRNAs) across all mammalian tissues
and cell lines remains a major challenge. Previously, mouse lncRNAs were identified using …

[HTML][HTML] Long noncoding RNAs: cellular address codes in development and disease

PJ Batista, HY Chang - Cell, 2013 - cell.com
In biology as in real estate, location is a cardinal organizational principle that dictates the
accessibility and flow of informational traffic. An essential question in nuclear organization is …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

lncRNAs: linking RNA to chromatin

JL Rinn - Cold Spring Harbor perspectives in biology, 2014 - cshperspectives.cshlp.org
Numerous studies over the past decade have identified increasing numbers of long
noncoding RNAs (lncRNAs) across many organisms. Research since has shown that …

Significance of lncRNA abundance to function

I Grammatikakis, A Lal - Mammalian Genome, 2022 - Springer
Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse cellular processes.
Although the vast majority of lncRNAs are expressed at lower levels compared to …