Background Sepsis involves aberrant immune responses to infection, but the exact nature of
this immune dysfunction remains poorly defined. Bacterial endotoxins like …

The rapid development in septic patients of features of marked immunosuppression
associated with increased risk of nosocomial infections and mortality represents the rational …

Sepsis is a life-threatening condition that occurs when the body responds to an infection
damaging its own tissues. Sepsis survivors sometimes suffer from immunosuppression …

Patients that suffer from sepsis exhibit an early hyper-inflammatory immune response which
can lead to organ failure and death. In our study, we assessed the immune modulation in the …

Background Sepsis is defined as a life-threatening condition, resulting from a dysregulated
and harmful response of the hosts' immune system to infection. Apart from this, the (over-) …

Background As early and appropriate care of severe septic patients is associated with better
outcome, understanding of the very first events in the disease process is needed. Pan …

Abstract Development of a dysregulated immune response discriminates sepsis from
uncomplicated infection. Currently used biomarkers fail to describe simultaneously occurring …

Sepsis is a dynamic state that progresses at variable rates and has life-threatening
consequences. Staging patients along the sepsis timeline requires a thorough knowledge of …

Background Inter-individual variability during sepsis limits appropriate triage of patients.
Identifying, at first clinical presentation, gene expression signatures that predict subsequent …

There is currently no reliable tool available to measure immune dysfunction in septic
patients in the clinical setting. This proof-of-concept study assesses the potential of gene …