Read mapping is a fundamental, yet computationally-expensive step in many genomics
applications. It is used to identify potential matches and differences between fragments …

Read mapping is a fundamental step in many genomics applications. It is used to identify
potential matches and differences between fragments (called reads) of a sequenced …

Genome analysis fundamentally starts with a process known as read mapping, where
sequenced fragments of an organism's genome are compared against a reference genome …

Read alignment is a time-consuming step in genome sequencing analysis. The most widely
used software for read alignment, BWA-MEM, and the recently published faster version BWA …

High throughput sequencing (HTS) platforms generate unprecedented amounts of data that
introduce challenges for processing and downstream analysis. While tools that report the …

When choosing a read mapper, one faces the trade off between speed and the ability to map
reads in highly polymorphic regions. Here, we report NextGenMap, a fast and accurate read …

Background Seed location filtering is critical in DNA read mapping, a process where billions
of DNA fragments (reads) sampled from a donor are mapped onto a reference genome to …

Abstract Background High Throughput Sequencing (HTS) is now heavily exploited for
genome (re-) sequencing, metagenomics, epigenomics, and transcriptomics and requires …

Computational genomics is an emerging field that is enabling us to reveal the origins of life
and the genetic basis of diseases such as cancer. Next Generation Sequencing (NGS) …

When computing alignments of DNA sequences to a large genome, a key element in
achieving high processing throughput is to prioritize locations in the genome where high …