J Stephen, HE Scales, RA Benson, D Erben, P Garside… - npj Vaccines, 2017 - nature.com
There are over 6 billion vaccine doses administered each year, most containing aluminium- based adjuvants, yet we still do not have a complete understanding of their mechanisms of …
CJ Desmet - Biological DNA Sensor, 2014 - Elsevier
Aluminum-based adjuvants (alum) are among the oldest and most widely used vaccine adjuvants. After decades of largely empirical use, the last years have witnessed a flurry of …
Adjuvants such as the aluminum compounds (alum) have been dominantly used in many vaccines due to their immunopotentiation and safety records since 1920s. However, how …
Aluminum-containing adjuvants have been used for over 90 years to enhance the immune response to vaccines. Recent work has significantly advanced our understanding of the …
S Kooijman, J Brummelman, CACM van Els, F Marino… - PLoS …, 2018 - journals.plos.org
Aluminum-based adjuvants have widely been used in human vaccines since 1926. In the absence of antigens, aluminum-based adjuvants can initiate the inflammatory preparedness …
TR Ghimire, RA Benson, P Garside, JM Brewer - Immunology letters, 2012 - Elsevier
Aluminium adjuvants (alum) have been the only widely approved adjuvants for use in human vaccines since the 1920s, however, the mechanism of action of these adjuvants …
E Oleszycka, EC Lavelle - Current opinion in immunology, 2014 - Elsevier
Highlights•The role of NLRP3 in alum adjuvanticity is unresolved.•Alum is sensed via its interactions with cell membrane lipids in dendritic cells.•Alum drives Syk-PI3 kinase …
Y Lu, G Liu - Human Vaccines & Immunotherapeutics, 2022 - Taylor & Francis
Alum adjuvant has always been the first choice when designing a vaccine. Conventional aluminum adjuvant includes aluminum hydroxide, aluminum phosphate, and amorphous …
S Allan - Nature Reviews Immunology, 2008 - nature.com
Aluminum hydroxide (alum) is a widely used adjuvant in human vaccines, but its mechanism of action remains ill-defined. In a new study, Lambrecht and colleagues find that a key factor …