Public interest in vaccines is at an all-time high following the SARS-CoV-2 global pandemic.
Currently, over 6 billion doses of various vaccines are administered globally each year. Most …

There are over 6 billion vaccine doses administered each year, most containing aluminium-
based adjuvants, yet we still do not have a complete understanding of their mechanisms of …

Aluminum-based adjuvants (alum) are among the oldest and most widely used vaccine
adjuvants. After decades of largely empirical use, the last years have witnessed a flurry of …

Adjuvants such as the aluminum compounds (alum) have been dominantly used in many
vaccines due to their immunopotentiation and safety records since 1920s. However, how …

Aluminum-containing adjuvants have been used for over 90 years to enhance the immune
response to vaccines. Recent work has significantly advanced our understanding of the …

Aluminum-based adjuvants have widely been used in human vaccines since 1926. In the
absence of antigens, aluminum-based adjuvants can initiate the inflammatory preparedness …

Aluminium adjuvants (alum) have been the only widely approved adjuvants for use in
human vaccines since the 1920s, however, the mechanism of action of these adjuvants …

Highlights•The role of NLRP3 in alum adjuvanticity is unresolved.•Alum is sensed via its
interactions with cell membrane lipids in dendritic cells.•Alum drives Syk-PI3 kinase …

Alum adjuvant has always been the first choice when designing a vaccine. Conventional
aluminum adjuvant includes aluminum hydroxide, aluminum phosphate, and amorphous …

Aluminum hydroxide (alum) is a widely used adjuvant in human vaccines, but its mechanism
of action remains ill-defined. In a new study, Lambrecht and colleagues find that a key factor …