Effective cancer treatment has been precluded by the presence of various forms of
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …

Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy.
However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may …

Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

With the proliferating studies of human cancers by single-cell RNA sequencing technique
(scRNA-seq), cellular heterogeneity, immune landscape and pathogenesis within diverse …

Assays to study cancer cell responses to pharmacologic or genetic perturbations are
typically restricted to using simple phenotypic readouts such as proliferation rate. Information …

Within a tumor, cancer cells exist in different states that are associated with distinct tumor
functions, including proliferation, differentiation, invasion, metastasis, and resistance to anti …

The emerging single-cell RNA-Seq (scRNA-Seq) technology holds the promise to
revolutionize our understanding of diseases and associated biological processes at an …

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ
between individual patients and even among individual tumor regions. In recent years, large …

Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Background Preclinical studies require models that recapitulate the cellular diversity of
human tumors and provide insight into the drug sensitivities of specific cellular populations …