Background Neurodegenerative disorders are a group of age-associated diseases
characterized by progressive degeneration of the structure and function of the CNS. Two key …

The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …

Located at the interface of the circulation system and the CNS, the basement membrane
(BM) is well positioned to regulate blood–brain barrier (BBB) integrity. Given the important …

The blood-brain barrier (BBB) is composed of specific tight junction proteins and
transporters expressed on the lining of endothelial cells of the vasculature in the brain. The …

Over the past decade, multiple sclerosis (MS), a chronic neuroinflammatory disease with
severe personal and social consequences, has undergone a steady increase in incidence …

The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …

The cerebral vasculature serves as the crossroads of the CNS, supporting exchange of
nutrients, metabolic wastes, solutes and cells between the compartments of the brain …

The interface between the blood circulation and the neural tissue features unique
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

The blood‐brain barrier (BBB) is essential for a functional neurovascular unit. Most studies
focused on the cells forming the BBB, but very few studied the basement membrane (BM) of …